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Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease

Grayscale abdomen ultrasound (US) is routinely performed in pregnant women with suspected pregnancy-related liver dysfunction, but its diagnostic yield is very low. We aimed to investigate the association between Doppler-US findings, liver stiffness measurement (LSM) and different causes of pregnanc...

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Autores principales: Serra, Carla, Dajti, Elton, De Molo, Chiara, Montaguti, Elisa, Porro, Alberto, Seidenari, Anna, Angilletta, Emiliana, Bernardi, Vito, Salsi, Ginevra, Bakken, Sofia Maria, Montagnani, Marco, Mazzella, Giuseppe, Azzaroli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962049/
https://www.ncbi.nlm.nih.gov/pubmed/36836188
http://dx.doi.org/10.3390/jcm12041653
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author Serra, Carla
Dajti, Elton
De Molo, Chiara
Montaguti, Elisa
Porro, Alberto
Seidenari, Anna
Angilletta, Emiliana
Bernardi, Vito
Salsi, Ginevra
Bakken, Sofia Maria
Montagnani, Marco
Mazzella, Giuseppe
Azzaroli, Francesco
author_facet Serra, Carla
Dajti, Elton
De Molo, Chiara
Montaguti, Elisa
Porro, Alberto
Seidenari, Anna
Angilletta, Emiliana
Bernardi, Vito
Salsi, Ginevra
Bakken, Sofia Maria
Montagnani, Marco
Mazzella, Giuseppe
Azzaroli, Francesco
author_sort Serra, Carla
collection PubMed
description Grayscale abdomen ultrasound (US) is routinely performed in pregnant women with suspected pregnancy-related liver dysfunction, but its diagnostic yield is very low. We aimed to investigate the association between Doppler-US findings, liver stiffness measurement (LSM) and different causes of pregnancy-related liver dysfunction. This is a prospective cohort study of pregnant women referred to our tertiary center for any suspected gastrointestinal disease between 2017 and 2019 and undergoing Doppler-US and liver elastography. Patients with previous liver disease were excluded from the analysis. For group comparisons of categorical and continuous variables, the chi-square test or Mann–Whitney test, and the McNemar test were used, as appropriate. A total of 112 patients were included in the final analysis, of whom 41 (36.6%) presented with suspected liver disease: 23 intrahepatic cholestasis of pregnancy (ICP), six with gestational hypertensive disorders and 12 cases with undetermined causes of elevated liver enzymes. Values of LSM were higher and significantly associated with a diagnosis of gestational hypertensive disorder (AUROC = 0.815). No significant differences at Doppler-US or LSM were found between ICP patients and controls. Patients with undetermined causes of hypertransaminasemia showed higher hepatic and splenic resistive indexes than controls, suggesting splanchnic congestion. The evaluation of Doppler-US and liver elastography is clinically useful in patients with suspected liver dysfunction during pregnancy. Liver stiffness represents a promising non-invasive tool for the assessment of patients with gestational hypertensive disorders.
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spelling pubmed-99620492023-02-26 Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease Serra, Carla Dajti, Elton De Molo, Chiara Montaguti, Elisa Porro, Alberto Seidenari, Anna Angilletta, Emiliana Bernardi, Vito Salsi, Ginevra Bakken, Sofia Maria Montagnani, Marco Mazzella, Giuseppe Azzaroli, Francesco J Clin Med Article Grayscale abdomen ultrasound (US) is routinely performed in pregnant women with suspected pregnancy-related liver dysfunction, but its diagnostic yield is very low. We aimed to investigate the association between Doppler-US findings, liver stiffness measurement (LSM) and different causes of pregnancy-related liver dysfunction. This is a prospective cohort study of pregnant women referred to our tertiary center for any suspected gastrointestinal disease between 2017 and 2019 and undergoing Doppler-US and liver elastography. Patients with previous liver disease were excluded from the analysis. For group comparisons of categorical and continuous variables, the chi-square test or Mann–Whitney test, and the McNemar test were used, as appropriate. A total of 112 patients were included in the final analysis, of whom 41 (36.6%) presented with suspected liver disease: 23 intrahepatic cholestasis of pregnancy (ICP), six with gestational hypertensive disorders and 12 cases with undetermined causes of elevated liver enzymes. Values of LSM were higher and significantly associated with a diagnosis of gestational hypertensive disorder (AUROC = 0.815). No significant differences at Doppler-US or LSM were found between ICP patients and controls. Patients with undetermined causes of hypertransaminasemia showed higher hepatic and splenic resistive indexes than controls, suggesting splanchnic congestion. The evaluation of Doppler-US and liver elastography is clinically useful in patients with suspected liver dysfunction during pregnancy. Liver stiffness represents a promising non-invasive tool for the assessment of patients with gestational hypertensive disorders. MDPI 2023-02-19 /pmc/articles/PMC9962049/ /pubmed/36836188 http://dx.doi.org/10.3390/jcm12041653 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serra, Carla
Dajti, Elton
De Molo, Chiara
Montaguti, Elisa
Porro, Alberto
Seidenari, Anna
Angilletta, Emiliana
Bernardi, Vito
Salsi, Ginevra
Bakken, Sofia Maria
Montagnani, Marco
Mazzella, Giuseppe
Azzaroli, Francesco
Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title_full Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title_fullStr Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title_full_unstemmed Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title_short Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
title_sort utility of doppler-ultrasound and liver elastography in the evaluation of patients with suspected pregnancy-related liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962049/
https://www.ncbi.nlm.nih.gov/pubmed/36836188
http://dx.doi.org/10.3390/jcm12041653
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