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Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress

Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, and cognitive and behavioural problems. Stress disrupts the homeostatic milieu of pregnancy by altering inflammatory and neuroendocrine...

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Autores principales: Lopes, Nayara A., Ambeskovic, Mirela, King, Stephanie E., Faraji, Jamshid, Soltanpour, Nasrin, Falkenberg, Erin A., Scheidl, Taylor, Patel, Mansi, Fang, Xin, Metz, Gerlinde A. S., Olson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962069/
https://www.ncbi.nlm.nih.gov/pubmed/36835144
http://dx.doi.org/10.3390/ijms24043734
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author Lopes, Nayara A.
Ambeskovic, Mirela
King, Stephanie E.
Faraji, Jamshid
Soltanpour, Nasrin
Falkenberg, Erin A.
Scheidl, Taylor
Patel, Mansi
Fang, Xin
Metz, Gerlinde A. S.
Olson, David M.
author_facet Lopes, Nayara A.
Ambeskovic, Mirela
King, Stephanie E.
Faraji, Jamshid
Soltanpour, Nasrin
Falkenberg, Erin A.
Scheidl, Taylor
Patel, Mansi
Fang, Xin
Metz, Gerlinde A. S.
Olson, David M.
author_sort Lopes, Nayara A.
collection PubMed
description Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, and cognitive and behavioural problems. Stress disrupts the homeostatic milieu of pregnancy by altering inflammatory and neuroendocrine mediators. These stress-induced phenotypic changes can be passed on to the offspring epigenetically. We investigated the effects of gestational chronic variable stress (CVS) in rats using restraint and social isolation stress in the parental F0 generation and its transgenerational transmission across three generations of female offspring (F1–F3). A subset of F1 rats was housed in an enriched environment (EE) to mitigate the adverse effects of CVS. We found that CVS is transmitted across generations and induces inflammatory changes in the uterus. CVS did not alter any gestational lengths or birth weights. However, inflammatory and endocrine markers changed in the uterine tissues of stressed mothers and their offspring, suggesting that stress is transgenerationally transmitted. The F2 offspring reared in EE had increased birth weights, but their uterine gene expression patterns remained comparable to those of stressed animals. Thus, ancestral CVS induced changes transgenerationally in fetal programming of uterine stress markers over three generations of offspring, and EE housing did not mitigate these effects.
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spelling pubmed-99620692023-02-26 Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress Lopes, Nayara A. Ambeskovic, Mirela King, Stephanie E. Faraji, Jamshid Soltanpour, Nasrin Falkenberg, Erin A. Scheidl, Taylor Patel, Mansi Fang, Xin Metz, Gerlinde A. S. Olson, David M. Int J Mol Sci Article Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, and cognitive and behavioural problems. Stress disrupts the homeostatic milieu of pregnancy by altering inflammatory and neuroendocrine mediators. These stress-induced phenotypic changes can be passed on to the offspring epigenetically. We investigated the effects of gestational chronic variable stress (CVS) in rats using restraint and social isolation stress in the parental F0 generation and its transgenerational transmission across three generations of female offspring (F1–F3). A subset of F1 rats was housed in an enriched environment (EE) to mitigate the adverse effects of CVS. We found that CVS is transmitted across generations and induces inflammatory changes in the uterus. CVS did not alter any gestational lengths or birth weights. However, inflammatory and endocrine markers changed in the uterine tissues of stressed mothers and their offspring, suggesting that stress is transgenerationally transmitted. The F2 offspring reared in EE had increased birth weights, but their uterine gene expression patterns remained comparable to those of stressed animals. Thus, ancestral CVS induced changes transgenerationally in fetal programming of uterine stress markers over three generations of offspring, and EE housing did not mitigate these effects. MDPI 2023-02-13 /pmc/articles/PMC9962069/ /pubmed/36835144 http://dx.doi.org/10.3390/ijms24043734 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lopes, Nayara A.
Ambeskovic, Mirela
King, Stephanie E.
Faraji, Jamshid
Soltanpour, Nasrin
Falkenberg, Erin A.
Scheidl, Taylor
Patel, Mansi
Fang, Xin
Metz, Gerlinde A. S.
Olson, David M.
Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title_full Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title_fullStr Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title_full_unstemmed Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title_short Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress
title_sort environmental enrichment promotes transgenerational programming of uterine inflammatory and stress markers comparable to gestational chronic variable stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962069/
https://www.ncbi.nlm.nih.gov/pubmed/36835144
http://dx.doi.org/10.3390/ijms24043734
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