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Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion of omega-3 fatty acids in the diet and a reduced risk for depression. The present study evaluated the effectiveness of omega-3 fatty acid supplements...

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Autores principales: Mehdi, Seema, Manohar, Kishor, Shariff, Atiqulla, Kinattingal, Nabeel, Wani, Shahid Ud Din, Alshehri, Sultan, Imam, Mohammad T., Shakeel, Faiyaz, Krishna, Kamsagara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962071/
https://www.ncbi.nlm.nih.gov/pubmed/36836458
http://dx.doi.org/10.3390/jpm13020224
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author Mehdi, Seema
Manohar, Kishor
Shariff, Atiqulla
Kinattingal, Nabeel
Wani, Shahid Ud Din
Alshehri, Sultan
Imam, Mohammad T.
Shakeel, Faiyaz
Krishna, Kamsagara L.
author_facet Mehdi, Seema
Manohar, Kishor
Shariff, Atiqulla
Kinattingal, Nabeel
Wani, Shahid Ud Din
Alshehri, Sultan
Imam, Mohammad T.
Shakeel, Faiyaz
Krishna, Kamsagara L.
author_sort Mehdi, Seema
collection PubMed
description Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion of omega-3 fatty acids in the diet and a reduced risk for depression. The present study evaluated the effectiveness of omega-3 fatty acid supplements in alleviating depressive symptoms in patients with mild to moderate depression. A total of 165 patients suffering from mild to moderated depression were randomized to receive omega-3 fatty acid supplementation, an antidepressant (single agent), or a combination of an antidepressant and omega-3 fatty acid supplementation. The clinical features of depression were assessed using the Hamilton Depression Rating Scale (HDRS) during the follow-up period. A statistically significant improvement in depressive symptoms was observed from baseline to first, second and third follow-ups within each treatment arm as measured by HRDS scores (p = 0.00001). Further, the HDRS scores at the third follow-up were significantly lower in patients on combination therapy of omega-3 fatty acid supplement and antidepressants (arm-3) than the patients on the omega-3 fatty acid supplement alone (arm-1) [Q = 5.89; p = 0.0001] or the patients taking an antidepressant alone (arm 2) [Q = 4.36; p = 0.0068]. The combination of an omega-3 fatty acid supplement and an antidepressant elicited significantly higher improvement in depressive symptoms than the supplement or the antidepressant alone.
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spelling pubmed-99620712023-02-26 Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study Mehdi, Seema Manohar, Kishor Shariff, Atiqulla Kinattingal, Nabeel Wani, Shahid Ud Din Alshehri, Sultan Imam, Mohammad T. Shakeel, Faiyaz Krishna, Kamsagara L. J Pers Med Article Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion of omega-3 fatty acids in the diet and a reduced risk for depression. The present study evaluated the effectiveness of omega-3 fatty acid supplements in alleviating depressive symptoms in patients with mild to moderate depression. A total of 165 patients suffering from mild to moderated depression were randomized to receive omega-3 fatty acid supplementation, an antidepressant (single agent), or a combination of an antidepressant and omega-3 fatty acid supplementation. The clinical features of depression were assessed using the Hamilton Depression Rating Scale (HDRS) during the follow-up period. A statistically significant improvement in depressive symptoms was observed from baseline to first, second and third follow-ups within each treatment arm as measured by HRDS scores (p = 0.00001). Further, the HDRS scores at the third follow-up were significantly lower in patients on combination therapy of omega-3 fatty acid supplement and antidepressants (arm-3) than the patients on the omega-3 fatty acid supplement alone (arm-1) [Q = 5.89; p = 0.0001] or the patients taking an antidepressant alone (arm 2) [Q = 4.36; p = 0.0068]. The combination of an omega-3 fatty acid supplement and an antidepressant elicited significantly higher improvement in depressive symptoms than the supplement or the antidepressant alone. MDPI 2023-01-27 /pmc/articles/PMC9962071/ /pubmed/36836458 http://dx.doi.org/10.3390/jpm13020224 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mehdi, Seema
Manohar, Kishor
Shariff, Atiqulla
Kinattingal, Nabeel
Wani, Shahid Ud Din
Alshehri, Sultan
Imam, Mohammad T.
Shakeel, Faiyaz
Krishna, Kamsagara L.
Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title_full Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title_fullStr Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title_full_unstemmed Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title_short Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study
title_sort omega-3 fatty acids supplementation in the treatment of depression: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962071/
https://www.ncbi.nlm.nih.gov/pubmed/36836458
http://dx.doi.org/10.3390/jpm13020224
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