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Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis

This study evaluates if there is an association between lifestyle changes and the risk of small vessel disease (SVD) as measured by cerebral white matter hyperintensities (WMH) estimated by the automatic retinal image analysis (ARIA) method. We recruited 274 individuals into a community cohort study...

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Autores principales: Lai, Maria, Lee, Jack, Li, Xinxin, Kwok, Chloe, Chong, Marc, Zee, Benny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962075/
https://www.ncbi.nlm.nih.gov/pubmed/36834224
http://dx.doi.org/10.3390/ijerph20043530
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author Lai, Maria
Lee, Jack
Li, Xinxin
Kwok, Chloe
Chong, Marc
Zee, Benny
author_facet Lai, Maria
Lee, Jack
Li, Xinxin
Kwok, Chloe
Chong, Marc
Zee, Benny
author_sort Lai, Maria
collection PubMed
description This study evaluates if there is an association between lifestyle changes and the risk of small vessel disease (SVD) as measured by cerebral white matter hyperintensities (WMH) estimated by the automatic retinal image analysis (ARIA) method. We recruited 274 individuals into a community cohort study. Subjects were assessed at baseline and annually with the Health-Promoting Lifestyle Profile II Questionnaire (HPLP-II) and underwent a simple physical assessment. Retinal images were taken using a non-mydriatic digital fundus camera to evaluate the level of WMH estimated by ARIA (ARIA-WMH) to measure the risk of small vessel disease. We calculated the changes from baseline to one year for the six domains of HPLP-II and analysed the relationship with the ARIA-WMH change. A total of 193 (70%) participants completed both the HPLP-II and ARIA-WMH assessments. The mean age was 59.1 ± 9.4 years, and 76.2% (147) were women. HPLP-II was moderate (Baseline, 138.96 ± 20.93; One-year, 141.97 ± 21.85). We observed a significant difference in ARIA-WMH change between diabetes and non-diabetes subjects (0.03 vs. −0.008, respectively, p = 0.03). A multivariate analysis model showed a significant interaction between the health responsibility (HR) domain and diabetes (p = 0.005). For non-diabetes subgroups, those with improvement in the HR domain had significantly decreased in ARIA-WMH than those without HR improvement (−0.04 vs. 0.02, respectively, p = 0.003). The physical activity domain was negatively related to the change in ARIA-WMH (p = 0.02). In conclusion, this study confirms that there is a significant association between lifestyle changes and ARIA-WMH. Furthermore, increasing health responsibility for non-diabetes subjects reduces the risk of having severe white matter hyperintensities.
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spelling pubmed-99620752023-02-26 Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis Lai, Maria Lee, Jack Li, Xinxin Kwok, Chloe Chong, Marc Zee, Benny Int J Environ Res Public Health Article This study evaluates if there is an association between lifestyle changes and the risk of small vessel disease (SVD) as measured by cerebral white matter hyperintensities (WMH) estimated by the automatic retinal image analysis (ARIA) method. We recruited 274 individuals into a community cohort study. Subjects were assessed at baseline and annually with the Health-Promoting Lifestyle Profile II Questionnaire (HPLP-II) and underwent a simple physical assessment. Retinal images were taken using a non-mydriatic digital fundus camera to evaluate the level of WMH estimated by ARIA (ARIA-WMH) to measure the risk of small vessel disease. We calculated the changes from baseline to one year for the six domains of HPLP-II and analysed the relationship with the ARIA-WMH change. A total of 193 (70%) participants completed both the HPLP-II and ARIA-WMH assessments. The mean age was 59.1 ± 9.4 years, and 76.2% (147) were women. HPLP-II was moderate (Baseline, 138.96 ± 20.93; One-year, 141.97 ± 21.85). We observed a significant difference in ARIA-WMH change between diabetes and non-diabetes subjects (0.03 vs. −0.008, respectively, p = 0.03). A multivariate analysis model showed a significant interaction between the health responsibility (HR) domain and diabetes (p = 0.005). For non-diabetes subgroups, those with improvement in the HR domain had significantly decreased in ARIA-WMH than those without HR improvement (−0.04 vs. 0.02, respectively, p = 0.003). The physical activity domain was negatively related to the change in ARIA-WMH (p = 0.02). In conclusion, this study confirms that there is a significant association between lifestyle changes and ARIA-WMH. Furthermore, increasing health responsibility for non-diabetes subjects reduces the risk of having severe white matter hyperintensities. MDPI 2023-02-16 /pmc/articles/PMC9962075/ /pubmed/36834224 http://dx.doi.org/10.3390/ijerph20043530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lai, Maria
Lee, Jack
Li, Xinxin
Kwok, Chloe
Chong, Marc
Zee, Benny
Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title_full Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title_fullStr Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title_full_unstemmed Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title_short Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
title_sort lifestyle changes reduced estimated white matter hyperintensities based on retinal image analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962075/
https://www.ncbi.nlm.nih.gov/pubmed/36834224
http://dx.doi.org/10.3390/ijerph20043530
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