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Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study
Most patients with asthma can control their symptoms with a basic standard of medical care and with maintenance and rescue medication. However, between 5% and 10% of asthmatics worldwide do not achieve control of their symptoms and have recurrent exacerbations and respiratory difficulties. The objec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962091/ https://www.ncbi.nlm.nih.gov/pubmed/36839845 http://dx.doi.org/10.3390/pharmaceutics15020523 |
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author | Rojo-Tolosa, Susana González-Gutiérrez, María Victoria Sánchez-Martínez, José Antonio Jiménez-Gálvez, Gonzalo Pineda-Lancheros, Laura Elena Gálvez-Navas, José María Jiménez-Morales, Alberto Pérez-Ramírez, Cristina Morales-García, Concepción |
author_facet | Rojo-Tolosa, Susana González-Gutiérrez, María Victoria Sánchez-Martínez, José Antonio Jiménez-Gálvez, Gonzalo Pineda-Lancheros, Laura Elena Gálvez-Navas, José María Jiménez-Morales, Alberto Pérez-Ramírez, Cristina Morales-García, Concepción |
author_sort | Rojo-Tolosa, Susana |
collection | PubMed |
description | Most patients with asthma can control their symptoms with a basic standard of medical care and with maintenance and rescue medication. However, between 5% and 10% of asthmatics worldwide do not achieve control of their symptoms and have recurrent exacerbations and respiratory difficulties. The objective of the study was the real-life evaluation of the clinical improvement of patients with severe eosinophilic asthma treated with omalizumab, together with the search for biomarkers associated with the response. An observational retrospective cohort study was conducted that included patients with severe uncontrolled allergic asthma being treated with omalizumab. Three types of response were evaluated: lower use of oral corticosteroids, improvement in lung function, and reduction in exacerbations. A total of 110 patients under treatment with omalizumab were included, with a mean age of 48 ± 16 years. After 12 months had elapsed, significant reductions were found in the number of exacerbations, use of oral cortico-steroids and doses of inhaled corticosteroids (p < 0.001). Lung function and asthma control improved significantly (p < 0.001; p = 0.004) and eosinophil levels were significantly reduced (p = 0.004). Low scores in the Asthma Control Test were associated with the oral corticosteroid-saving effect; lower previous FEV1 levels and absence of chronic obstructive pulmonary disease (COPD) were related to improvement in lung function, and prior FEV1 values higher than 80% and absence of gastroesophageal reflux disease (GERD) with a reduction in exacerbations. The results of this study confirm the clinical benefit obtained after the introduction of omalizumab and the possible predictive biomarkers of response to the treatment. |
format | Online Article Text |
id | pubmed-9962091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99620912023-02-26 Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study Rojo-Tolosa, Susana González-Gutiérrez, María Victoria Sánchez-Martínez, José Antonio Jiménez-Gálvez, Gonzalo Pineda-Lancheros, Laura Elena Gálvez-Navas, José María Jiménez-Morales, Alberto Pérez-Ramírez, Cristina Morales-García, Concepción Pharmaceutics Article Most patients with asthma can control their symptoms with a basic standard of medical care and with maintenance and rescue medication. However, between 5% and 10% of asthmatics worldwide do not achieve control of their symptoms and have recurrent exacerbations and respiratory difficulties. The objective of the study was the real-life evaluation of the clinical improvement of patients with severe eosinophilic asthma treated with omalizumab, together with the search for biomarkers associated with the response. An observational retrospective cohort study was conducted that included patients with severe uncontrolled allergic asthma being treated with omalizumab. Three types of response were evaluated: lower use of oral corticosteroids, improvement in lung function, and reduction in exacerbations. A total of 110 patients under treatment with omalizumab were included, with a mean age of 48 ± 16 years. After 12 months had elapsed, significant reductions were found in the number of exacerbations, use of oral cortico-steroids and doses of inhaled corticosteroids (p < 0.001). Lung function and asthma control improved significantly (p < 0.001; p = 0.004) and eosinophil levels were significantly reduced (p = 0.004). Low scores in the Asthma Control Test were associated with the oral corticosteroid-saving effect; lower previous FEV1 levels and absence of chronic obstructive pulmonary disease (COPD) were related to improvement in lung function, and prior FEV1 values higher than 80% and absence of gastroesophageal reflux disease (GERD) with a reduction in exacerbations. The results of this study confirm the clinical benefit obtained after the introduction of omalizumab and the possible predictive biomarkers of response to the treatment. MDPI 2023-02-04 /pmc/articles/PMC9962091/ /pubmed/36839845 http://dx.doi.org/10.3390/pharmaceutics15020523 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rojo-Tolosa, Susana González-Gutiérrez, María Victoria Sánchez-Martínez, José Antonio Jiménez-Gálvez, Gonzalo Pineda-Lancheros, Laura Elena Gálvez-Navas, José María Jiménez-Morales, Alberto Pérez-Ramírez, Cristina Morales-García, Concepción Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title | Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title_full | Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title_fullStr | Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title_full_unstemmed | Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title_short | Impact of Omalizumab in Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study |
title_sort | impact of omalizumab in patients with severe uncontrolled asthma and possible predictive biomarkers of response: a real-life study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962091/ https://www.ncbi.nlm.nih.gov/pubmed/36839845 http://dx.doi.org/10.3390/pharmaceutics15020523 |
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