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The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia
This study aimed to assess the predictive performance of the National Early Warning Score 2 (NEWS2) to identify the early progression to severe disease in patients with community-acquired pneumonia (CAP). A prospective-cohort study was conducted among patients with CAP admitted to a university hospi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962139/ https://www.ncbi.nlm.nih.gov/pubmed/36828485 http://dx.doi.org/10.3390/tropicalmed8020068 |
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author | Tajarernmuang, Pattraporn Sanwirat, Pimchanok Inchai, Juthamas Phinyo, Phichayut Limsukon, Atikun |
author_facet | Tajarernmuang, Pattraporn Sanwirat, Pimchanok Inchai, Juthamas Phinyo, Phichayut Limsukon, Atikun |
author_sort | Tajarernmuang, Pattraporn |
collection | PubMed |
description | This study aimed to assess the predictive performance of the National Early Warning Score 2 (NEWS2) to identify the early progression to severe disease in patients with community-acquired pneumonia (CAP). A prospective-cohort study was conducted among patients with CAP admitted to a university hospital between October 2020 and December 2021. The endpoint of interest was the progression to severe CAP, defined as the requirement for a mechanical ventilator, a vasopressor, or death within 72 h after hospital admission. Among 260 patients, 53 (25.6%) had early progression to severe CAP. The median NEWS2 of the early progression group was higher than that of the non-progression group [8 (6–9) vs. 7 (5–8), p = 0.015, respectively]. The AUROC of NEWS2 to predict early progression to severe CAP was 0.61 (95% CI: 0.52–0.70), while IDSA/ATS minor criteria ≥ 3 had AUROC 0.56 (95% CI 0.48–0.65). The combination of NEWS2 ≥ 8, albumin level < 3 g/dL and BUN ≥ 30 mg/dL improved AUROC from 0.61 to 0.71 (p = 0.015). NEWS2 and IDSA/ATS minor criteria showed fair predictive-accuracy in predicting progression to severe CAP. The NEWS2 cut-off ≥ 8 in combination with low albumin and uremia improved predictive-accuracy, and could be easily used in general practice. |
format | Online Article Text |
id | pubmed-9962139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99621392023-02-26 The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia Tajarernmuang, Pattraporn Sanwirat, Pimchanok Inchai, Juthamas Phinyo, Phichayut Limsukon, Atikun Trop Med Infect Dis Article This study aimed to assess the predictive performance of the National Early Warning Score 2 (NEWS2) to identify the early progression to severe disease in patients with community-acquired pneumonia (CAP). A prospective-cohort study was conducted among patients with CAP admitted to a university hospital between October 2020 and December 2021. The endpoint of interest was the progression to severe CAP, defined as the requirement for a mechanical ventilator, a vasopressor, or death within 72 h after hospital admission. Among 260 patients, 53 (25.6%) had early progression to severe CAP. The median NEWS2 of the early progression group was higher than that of the non-progression group [8 (6–9) vs. 7 (5–8), p = 0.015, respectively]. The AUROC of NEWS2 to predict early progression to severe CAP was 0.61 (95% CI: 0.52–0.70), while IDSA/ATS minor criteria ≥ 3 had AUROC 0.56 (95% CI 0.48–0.65). The combination of NEWS2 ≥ 8, albumin level < 3 g/dL and BUN ≥ 30 mg/dL improved AUROC from 0.61 to 0.71 (p = 0.015). NEWS2 and IDSA/ATS minor criteria showed fair predictive-accuracy in predicting progression to severe CAP. The NEWS2 cut-off ≥ 8 in combination with low albumin and uremia improved predictive-accuracy, and could be easily used in general practice. MDPI 2023-01-17 /pmc/articles/PMC9962139/ /pubmed/36828485 http://dx.doi.org/10.3390/tropicalmed8020068 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tajarernmuang, Pattraporn Sanwirat, Pimchanok Inchai, Juthamas Phinyo, Phichayut Limsukon, Atikun The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title | The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title_full | The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title_fullStr | The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title_full_unstemmed | The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title_short | The National Early Warning Score 2(NEWS2) to Predict Early Progression to Severe Community-Acquired Pneumonia |
title_sort | national early warning score 2(news2) to predict early progression to severe community-acquired pneumonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962139/ https://www.ncbi.nlm.nih.gov/pubmed/36828485 http://dx.doi.org/10.3390/tropicalmed8020068 |
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