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Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962161/ https://www.ncbi.nlm.nih.gov/pubmed/36835793 http://dx.doi.org/10.3390/jcm12041257 |
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author | Nozaki, Yuji Yoshihisa, Akiomi Sato, Yu Ohara, Himika Sugawara, Yukiko Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Takeishi, Yasuchika |
author_facet | Nozaki, Yuji Yoshihisa, Akiomi Sato, Yu Ohara, Himika Sugawara, Yukiko Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Takeishi, Yasuchika |
author_sort | Nozaki, Yuji |
collection | PubMed |
description | Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021 (n = 348). Dialysis patients (n = 26) were excluded. The patients were divided into four groups based on the absence/presence of hypochloremia (<98 mmol/L) at discharge from their first and second hospitalizations: Group A (patients without hypochloremia at their first and second hospitalizations, n = 243); Group B (those with hypochloremia at their first hospitalization and without hypochloremia at their second hospitalization, n = 29); Group C (those without hypochloremia at their first hospitalization and with hypochloremia at their second hospitalization, n = 34); and Group D (those with hypochloremia at their first and second hospitalizations, n = 16). Results: a Kaplan–Meier analysis revealed that all-cause mortality and cardiac mortality were the highest in Group D compared to the other groups. A multivariable Cox proportional hazard analysis revealed that persistent hypochloremia was independently associated with both all-cause death (hazard ratio 3.490, p < 0.001) and cardiac death (hazard ratio 3.919, p < 0.001). Conclusions: In patients with HF, prolonged hypochloremia over two hospitalizations is associated with an adverse prognosis. |
format | Online Article Text |
id | pubmed-9962161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99621612023-02-26 Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure Nozaki, Yuji Yoshihisa, Akiomi Sato, Yu Ohara, Himika Sugawara, Yukiko Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Takeishi, Yasuchika J Clin Med Article Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021 (n = 348). Dialysis patients (n = 26) were excluded. The patients were divided into four groups based on the absence/presence of hypochloremia (<98 mmol/L) at discharge from their first and second hospitalizations: Group A (patients without hypochloremia at their first and second hospitalizations, n = 243); Group B (those with hypochloremia at their first hospitalization and without hypochloremia at their second hospitalization, n = 29); Group C (those without hypochloremia at their first hospitalization and with hypochloremia at their second hospitalization, n = 34); and Group D (those with hypochloremia at their first and second hospitalizations, n = 16). Results: a Kaplan–Meier analysis revealed that all-cause mortality and cardiac mortality were the highest in Group D compared to the other groups. A multivariable Cox proportional hazard analysis revealed that persistent hypochloremia was independently associated with both all-cause death (hazard ratio 3.490, p < 0.001) and cardiac death (hazard ratio 3.919, p < 0.001). Conclusions: In patients with HF, prolonged hypochloremia over two hospitalizations is associated with an adverse prognosis. MDPI 2023-02-05 /pmc/articles/PMC9962161/ /pubmed/36835793 http://dx.doi.org/10.3390/jcm12041257 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nozaki, Yuji Yoshihisa, Akiomi Sato, Yu Ohara, Himika Sugawara, Yukiko Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Takeishi, Yasuchika Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title | Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title_full | Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title_fullStr | Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title_full_unstemmed | Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title_short | Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure |
title_sort | persistent hypochloremia is associated with adverse prognosis in patients repeatedly hospitalized for heart failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962161/ https://www.ncbi.nlm.nih.gov/pubmed/36835793 http://dx.doi.org/10.3390/jcm12041257 |
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