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Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure

Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021...

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Autores principales: Nozaki, Yuji, Yoshihisa, Akiomi, Sato, Yu, Ohara, Himika, Sugawara, Yukiko, Abe, Satoshi, Misaka, Tomofumi, Sato, Takamasa, Oikawa, Masayoshi, Kobayashi, Atsushi, Yamaki, Takayoshi, Nakazato, Kazuhiko, Takeishi, Yasuchika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962161/
https://www.ncbi.nlm.nih.gov/pubmed/36835793
http://dx.doi.org/10.3390/jcm12041257
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author Nozaki, Yuji
Yoshihisa, Akiomi
Sato, Yu
Ohara, Himika
Sugawara, Yukiko
Abe, Satoshi
Misaka, Tomofumi
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Takeishi, Yasuchika
author_facet Nozaki, Yuji
Yoshihisa, Akiomi
Sato, Yu
Ohara, Himika
Sugawara, Yukiko
Abe, Satoshi
Misaka, Tomofumi
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Takeishi, Yasuchika
author_sort Nozaki, Yuji
collection PubMed
description Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021 (n = 348). Dialysis patients (n = 26) were excluded. The patients were divided into four groups based on the absence/presence of hypochloremia (<98 mmol/L) at discharge from their first and second hospitalizations: Group A (patients without hypochloremia at their first and second hospitalizations, n = 243); Group B (those with hypochloremia at their first hospitalization and without hypochloremia at their second hospitalization, n = 29); Group C (those without hypochloremia at their first hospitalization and with hypochloremia at their second hospitalization, n = 34); and Group D (those with hypochloremia at their first and second hospitalizations, n = 16). Results: a Kaplan–Meier analysis revealed that all-cause mortality and cardiac mortality were the highest in Group D compared to the other groups. A multivariable Cox proportional hazard analysis revealed that persistent hypochloremia was independently associated with both all-cause death (hazard ratio 3.490, p < 0.001) and cardiac death (hazard ratio 3.919, p < 0.001). Conclusions: In patients with HF, prolonged hypochloremia over two hospitalizations is associated with an adverse prognosis.
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spelling pubmed-99621612023-02-26 Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure Nozaki, Yuji Yoshihisa, Akiomi Sato, Yu Ohara, Himika Sugawara, Yukiko Abe, Satoshi Misaka, Tomofumi Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Takeishi, Yasuchika J Clin Med Article Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021 (n = 348). Dialysis patients (n = 26) were excluded. The patients were divided into four groups based on the absence/presence of hypochloremia (<98 mmol/L) at discharge from their first and second hospitalizations: Group A (patients without hypochloremia at their first and second hospitalizations, n = 243); Group B (those with hypochloremia at their first hospitalization and without hypochloremia at their second hospitalization, n = 29); Group C (those without hypochloremia at their first hospitalization and with hypochloremia at their second hospitalization, n = 34); and Group D (those with hypochloremia at their first and second hospitalizations, n = 16). Results: a Kaplan–Meier analysis revealed that all-cause mortality and cardiac mortality were the highest in Group D compared to the other groups. A multivariable Cox proportional hazard analysis revealed that persistent hypochloremia was independently associated with both all-cause death (hazard ratio 3.490, p < 0.001) and cardiac death (hazard ratio 3.919, p < 0.001). Conclusions: In patients with HF, prolonged hypochloremia over two hospitalizations is associated with an adverse prognosis. MDPI 2023-02-05 /pmc/articles/PMC9962161/ /pubmed/36835793 http://dx.doi.org/10.3390/jcm12041257 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nozaki, Yuji
Yoshihisa, Akiomi
Sato, Yu
Ohara, Himika
Sugawara, Yukiko
Abe, Satoshi
Misaka, Tomofumi
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Takeishi, Yasuchika
Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title_full Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title_fullStr Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title_full_unstemmed Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title_short Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure
title_sort persistent hypochloremia is associated with adverse prognosis in patients repeatedly hospitalized for heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962161/
https://www.ncbi.nlm.nih.gov/pubmed/36835793
http://dx.doi.org/10.3390/jcm12041257
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