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Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection
A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu (II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the medium in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962186/ https://www.ncbi.nlm.nih.gov/pubmed/36826905 http://dx.doi.org/10.3390/jfb14020106 |
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author | Georgieva, Stela Todorov, Petar Staneva, Desislava Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo |
author_facet | Georgieva, Stela Todorov, Petar Staneva, Desislava Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo |
author_sort | Georgieva, Stela |
collection | PubMed |
description | A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu (II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the medium in which they are formed using voltammetric (cyclic) and spectral (UV-Vis and fluorimetric) analytical techniques. The resulting complexes were examined via IR spectroscopy to detect M-N and M-O oscillations and using the EPR approach in solution and in the solid phase to view the coordination and ligand binding regime. The possibility of the synergistic action of copper ions in the antivirus protection processes of cotton fibers coated in the same solvent with the newly obtained complex compounds was also investigated. One of the advantages is the formation of the complexes in an environment where the immobilization takes place, which contributes to increasing the efficiency of the process. The obtained results may serve as an aid for future more detailed biological studies of structure–activity relationships (SARs). |
format | Online Article Text |
id | pubmed-9962186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99621862023-02-26 Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection Georgieva, Stela Todorov, Petar Staneva, Desislava Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo J Funct Biomater Article A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu (II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the medium in which they are formed using voltammetric (cyclic) and spectral (UV-Vis and fluorimetric) analytical techniques. The resulting complexes were examined via IR spectroscopy to detect M-N and M-O oscillations and using the EPR approach in solution and in the solid phase to view the coordination and ligand binding regime. The possibility of the synergistic action of copper ions in the antivirus protection processes of cotton fibers coated in the same solvent with the newly obtained complex compounds was also investigated. One of the advantages is the formation of the complexes in an environment where the immobilization takes place, which contributes to increasing the efficiency of the process. The obtained results may serve as an aid for future more detailed biological studies of structure–activity relationships (SARs). MDPI 2023-02-14 /pmc/articles/PMC9962186/ /pubmed/36826905 http://dx.doi.org/10.3390/jfb14020106 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Georgieva, Stela Todorov, Petar Staneva, Desislava Grozdanov, Petar Nikolova, Ivanka Grabchev, Ivo Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title | Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title_full | Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title_fullStr | Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title_full_unstemmed | Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title_short | Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection |
title_sort | metal–peptide complexes with antimicrobial potential for cotton fiber protection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962186/ https://www.ncbi.nlm.nih.gov/pubmed/36826905 http://dx.doi.org/10.3390/jfb14020106 |
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