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External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia

Background: Methotrexate (MTX) is a key immunosuppressant for children with acute lymphoid leukemia (ALL), and it has a narrow therapeutic window and relatively high pharmacokinetic variability. Several population pharmacokinetic (PopPK) models of MTX in ALL children have been reported, but the vali...

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Detalles Bibliográficos
Autores principales:	Wang, Shengfeng, Yin, Qiufen, Yang, Minghua, Cheng, Zeneng, Xie, Feifan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962320/ https://www.ncbi.nlm.nih.gov/pubmed/36839891 http://dx.doi.org/10.3390/pharmaceutics15020569

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