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Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI

Perfusion imaging is preferred for identifying hypoperfusion in the management of acute ischemic stroke, but it is not always feasible/available. An alternative method for quantifying hypoperfusion, using FLAIR-hyperintense vessels (FHVs) in various vascular regions, has been proposed, with evidence...

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Autores principales: Bunker, Lisa D., Hillis, Argye E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962403/
https://www.ncbi.nlm.nih.gov/pubmed/36836089
http://dx.doi.org/10.3390/jcm12041554
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author Bunker, Lisa D.
Hillis, Argye E.
author_facet Bunker, Lisa D.
Hillis, Argye E.
author_sort Bunker, Lisa D.
collection PubMed
description Perfusion imaging is preferred for identifying hypoperfusion in the management of acute ischemic stroke, but it is not always feasible/available. An alternative method for quantifying hypoperfusion, using FLAIR-hyperintense vessels (FHVs) in various vascular regions, has been proposed, with evidence of a statistical relationship with perfusion-weighted imaging (PWI) deficits and behavior. However, additional validation is needed to confirm that areas of suspected hypoperfusion (per the location of FHVs) correspond to the location of perfusion deficits in PWI. We examined the association between the location of FHVs and perfusion deficits in PWI in 101 individuals with acute ischemic stroke, prior to the receipt of reperfusion therapies. FHVs and PWI lesions were scored as present/absent in six vascular regions (i.e., the ACA, PCA, and (four sub-regions of) the MCA territories). Chi-square analyses showed a significant relationship between the two imaging techniques for five vascular regions (the relationship in the ACA territory was underpowered). These results suggest that for most areas of the brain, the general location of FHVs corresponds to hypoperfusion in those same vascular territories in PWI. In conjunction with prior work, results support the use of estimating the amount and location of hypoperfusion using FLAIR imaging when perfusion imaging is not available.
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spelling pubmed-99624032023-02-26 Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI Bunker, Lisa D. Hillis, Argye E. J Clin Med Article Perfusion imaging is preferred for identifying hypoperfusion in the management of acute ischemic stroke, but it is not always feasible/available. An alternative method for quantifying hypoperfusion, using FLAIR-hyperintense vessels (FHVs) in various vascular regions, has been proposed, with evidence of a statistical relationship with perfusion-weighted imaging (PWI) deficits and behavior. However, additional validation is needed to confirm that areas of suspected hypoperfusion (per the location of FHVs) correspond to the location of perfusion deficits in PWI. We examined the association between the location of FHVs and perfusion deficits in PWI in 101 individuals with acute ischemic stroke, prior to the receipt of reperfusion therapies. FHVs and PWI lesions were scored as present/absent in six vascular regions (i.e., the ACA, PCA, and (four sub-regions of) the MCA territories). Chi-square analyses showed a significant relationship between the two imaging techniques for five vascular regions (the relationship in the ACA territory was underpowered). These results suggest that for most areas of the brain, the general location of FHVs corresponds to hypoperfusion in those same vascular territories in PWI. In conjunction with prior work, results support the use of estimating the amount and location of hypoperfusion using FLAIR imaging when perfusion imaging is not available. MDPI 2023-02-16 /pmc/articles/PMC9962403/ /pubmed/36836089 http://dx.doi.org/10.3390/jcm12041554 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bunker, Lisa D.
Hillis, Argye E.
Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title_full Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title_fullStr Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title_full_unstemmed Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title_short Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
title_sort location of hyperintense vessels on flair associated with the location of perfusion deficits in pwi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962403/
https://www.ncbi.nlm.nih.gov/pubmed/36836089
http://dx.doi.org/10.3390/jcm12041554
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