Multifaceted Nature of DNA Polymerase θ

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this revi...

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Detalles Bibliográficos
Autores principales: Kruchinin, Alexander A., Makarova, Alena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962433/
https://www.ncbi.nlm.nih.gov/pubmed/36835031
http://dx.doi.org/10.3390/ijms24043619
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author Kruchinin, Alexander A.
Makarova, Alena V.
author_facet Kruchinin, Alexander A.
Makarova, Alena V.
author_sort Kruchinin, Alexander A.
collection PubMed
description DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment.
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spelling pubmed-99624332023-02-26 Multifaceted Nature of DNA Polymerase θ Kruchinin, Alexander A. Makarova, Alena V. Int J Mol Sci Review DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment. MDPI 2023-02-10 /pmc/articles/PMC9962433/ /pubmed/36835031 http://dx.doi.org/10.3390/ijms24043619 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kruchinin, Alexander A.
Makarova, Alena V.
Multifaceted Nature of DNA Polymerase θ
title Multifaceted Nature of DNA Polymerase θ
title_full Multifaceted Nature of DNA Polymerase θ
title_fullStr Multifaceted Nature of DNA Polymerase θ
title_full_unstemmed Multifaceted Nature of DNA Polymerase θ
title_short Multifaceted Nature of DNA Polymerase θ
title_sort multifaceted nature of dna polymerase θ
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962433/
https://www.ncbi.nlm.nih.gov/pubmed/36835031
http://dx.doi.org/10.3390/ijms24043619
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