Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters

Minor genera actinomycetes are considered a promising source of new secondary metabolites. The strain Kribbella sp. CA-293567 produces sandramycin and kribbellichelins A & B In this work, we describe the complete genome sequencing of this strain and the in silico identification of biosynthetic g...

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Autores principales: Sánchez-Hidalgo, Marina, García, María Jesús, González, Ignacio, Oves-Costales, Daniel, Genilloud, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962454/
https://www.ncbi.nlm.nih.gov/pubmed/36838228
http://dx.doi.org/10.3390/microorganisms11020265
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author Sánchez-Hidalgo, Marina
García, María Jesús
González, Ignacio
Oves-Costales, Daniel
Genilloud, Olga
author_facet Sánchez-Hidalgo, Marina
García, María Jesús
González, Ignacio
Oves-Costales, Daniel
Genilloud, Olga
author_sort Sánchez-Hidalgo, Marina
collection PubMed
description Minor genera actinomycetes are considered a promising source of new secondary metabolites. The strain Kribbella sp. CA-293567 produces sandramycin and kribbellichelins A & B In this work, we describe the complete genome sequencing of this strain and the in silico identification of biosynthetic gene clusters (BGCs), focusing on the pathways encoding sandramycin and kribbellichelins A–B. We also present a comparative analysis of the biosynthetic potential of 38 publicly available genomes from Kribbella strains.
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spelling pubmed-99624542023-02-26 Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters Sánchez-Hidalgo, Marina García, María Jesús González, Ignacio Oves-Costales, Daniel Genilloud, Olga Microorganisms Article Minor genera actinomycetes are considered a promising source of new secondary metabolites. The strain Kribbella sp. CA-293567 produces sandramycin and kribbellichelins A & B In this work, we describe the complete genome sequencing of this strain and the in silico identification of biosynthetic gene clusters (BGCs), focusing on the pathways encoding sandramycin and kribbellichelins A–B. We also present a comparative analysis of the biosynthetic potential of 38 publicly available genomes from Kribbella strains. MDPI 2023-01-19 /pmc/articles/PMC9962454/ /pubmed/36838228 http://dx.doi.org/10.3390/microorganisms11020265 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Hidalgo, Marina
García, María Jesús
González, Ignacio
Oves-Costales, Daniel
Genilloud, Olga
Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title_full Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title_fullStr Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title_full_unstemmed Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title_short Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters
title_sort complete genome sequence analysis of kribbella sp. ca-293567 and identification of the kribbellichelins a & b and sandramycin biosynthetic gene clusters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962454/
https://www.ncbi.nlm.nih.gov/pubmed/36838228
http://dx.doi.org/10.3390/microorganisms11020265
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