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Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates

Peptide–drug conjugates are delivery systems for selective delivery of cytotoxic agents to target cancer cells. In this work, the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates is presented. The low nanomolar SRPK1 inhibitor, JH-VII-139-1, which is an analogue of Alectinib,...

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Detalles Bibliográficos
Autores principales:	Leonidis, George, Koukiali, Anastasia, Sigala, Ioanna, Tsimaratou, Katerina, Beis, Dimitris, Giannakouros, Thomas, Nikolakaki, Eleni, Sarli, Vasiliki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962512/ https://www.ncbi.nlm.nih.gov/pubmed/36839704 http://dx.doi.org/10.3390/pharmaceutics15020381

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