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Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease

Pseudorabies virus (PRV) is the pathogen of pseudorabies (PR), which belongs to the alpha herpesvirus subfamily with a double stranded DNA genome encoding approximately 70 proteins. PRV has many non-essential regions for replication, has a strong capacity to accommodate foreign genes, and more areas...

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Detalles Bibliográficos
Autores principales: Zhou, Mo, Abid, Muhammad, Cao, Shinuo, Zhu, Shanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962541/
https://www.ncbi.nlm.nih.gov/pubmed/36851584
http://dx.doi.org/10.3390/v15020370
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author Zhou, Mo
Abid, Muhammad
Cao, Shinuo
Zhu, Shanyuan
author_facet Zhou, Mo
Abid, Muhammad
Cao, Shinuo
Zhu, Shanyuan
author_sort Zhou, Mo
collection PubMed
description Pseudorabies virus (PRV) is the pathogen of pseudorabies (PR), which belongs to the alpha herpesvirus subfamily with a double stranded DNA genome encoding approximately 70 proteins. PRV has many non-essential regions for replication, has a strong capacity to accommodate foreign genes, and more areas for genetic modification. PRV is an ideal vaccine vector, and multivalent live virus-vectored vaccines can be developed using the gene-deleted PRV. The immune system continues to be stimulated by the gene-deleted PRVs and maintain a long immunity lasting more than 4 months. Here, we provide a brief overview of the biology of PRV, recombinant PRV construction methodology, the technology platform for efficiently constructing recombinant PRV, and the applications of recombinant PRV in vaccine development. This review summarizes the latest information on PRV usage in vaccine development against swine infectious diseases, and it offers novel perspectives for advancing preventive medicine through vaccinology.
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spelling pubmed-99625412023-02-26 Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease Zhou, Mo Abid, Muhammad Cao, Shinuo Zhu, Shanyuan Viruses Review Pseudorabies virus (PRV) is the pathogen of pseudorabies (PR), which belongs to the alpha herpesvirus subfamily with a double stranded DNA genome encoding approximately 70 proteins. PRV has many non-essential regions for replication, has a strong capacity to accommodate foreign genes, and more areas for genetic modification. PRV is an ideal vaccine vector, and multivalent live virus-vectored vaccines can be developed using the gene-deleted PRV. The immune system continues to be stimulated by the gene-deleted PRVs and maintain a long immunity lasting more than 4 months. Here, we provide a brief overview of the biology of PRV, recombinant PRV construction methodology, the technology platform for efficiently constructing recombinant PRV, and the applications of recombinant PRV in vaccine development. This review summarizes the latest information on PRV usage in vaccine development against swine infectious diseases, and it offers novel perspectives for advancing preventive medicine through vaccinology. MDPI 2023-01-28 /pmc/articles/PMC9962541/ /pubmed/36851584 http://dx.doi.org/10.3390/v15020370 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhou, Mo
Abid, Muhammad
Cao, Shinuo
Zhu, Shanyuan
Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title_full Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title_fullStr Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title_full_unstemmed Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title_short Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
title_sort recombinant pseudorabies virus usage in vaccine development against swine infectious disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962541/
https://www.ncbi.nlm.nih.gov/pubmed/36851584
http://dx.doi.org/10.3390/v15020370
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