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Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome

The gut–liver axis has been recognized as a potential pathway in which dietary factors may contribute to liver disease in people living with HIV (PLWH). The objective of this study was to explore associations between dietary quality, the fecal microbiome, the metabolome, and liver health in PLWH fro...

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Autores principales: Martin, Haley R., Sales Martinez, Sabrina, Stebliankin, Vitalii, Tamargo, Javier A., Campa, Adriana, Narasimhan, Giri, Hernandez, Jacqueline, Rodriguez, Jose A. Bastida, Teeman, Colby, Johnson, Angelique, Sherman, Kenneth E., Baum, Marianna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962547/
https://www.ncbi.nlm.nih.gov/pubmed/36837890
http://dx.doi.org/10.3390/metabo13020271
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author Martin, Haley R.
Sales Martinez, Sabrina
Stebliankin, Vitalii
Tamargo, Javier A.
Campa, Adriana
Narasimhan, Giri
Hernandez, Jacqueline
Rodriguez, Jose A. Bastida
Teeman, Colby
Johnson, Angelique
Sherman, Kenneth E.
Baum, Marianna K.
author_facet Martin, Haley R.
Sales Martinez, Sabrina
Stebliankin, Vitalii
Tamargo, Javier A.
Campa, Adriana
Narasimhan, Giri
Hernandez, Jacqueline
Rodriguez, Jose A. Bastida
Teeman, Colby
Johnson, Angelique
Sherman, Kenneth E.
Baum, Marianna K.
author_sort Martin, Haley R.
collection PubMed
description The gut–liver axis has been recognized as a potential pathway in which dietary factors may contribute to liver disease in people living with HIV (PLWH). The objective of this study was to explore associations between dietary quality, the fecal microbiome, the metabolome, and liver health in PLWH from the Miami Adult Studies on HIV (MASH) cohort. We performed a cross-sectional analysis of 50 PLWH from the MASH cohort and utilized the USDA Healthy Eating Index (HEI)–2015 to measure diet quality. A Fibrosis-4 Index (FIB-4) score < 1.45 was used as a strong indication that advanced liver fibrosis was not present. Stool samples and fasting blood plasma samples were collected. Bacterial composition was characterized using 16S rRNA sequencing. Metabolomics in plasma were determined using gas and liquid chromatography/mass spectrometry. Statistical analyses included biomarker identification using linear discriminant analysis effect size. Compared to participants with FIB-4 ≥ 1.45, participants with FIB-4 < 1.45 had higher intake of dairy (p = 0.006). Fibrosis-4 Index score was inversely correlated with seafood and plant protein HEI component score (r = −0.320, p = 0.022). The relative abundances of butyrate-producing taxa Ruminococcaceae, Roseburia, and Lachnospiraceae were higher in participants with FIB-4 < 1.45. Participants with FIB-4 < 1.45 also had higher levels of caffeine (p = 0.045) and related metabolites such as trigonelline (p = 0.008) and 1-methylurate (p = 0.023). Dietary components appear to be associated with the fecal microbiome and metabolome, and liver health in PLWH. Future studies should investigate whether targeting specific dietary components may reduce liver-related morbidity and mortality in PLWH.
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spelling pubmed-99625472023-02-26 Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome Martin, Haley R. Sales Martinez, Sabrina Stebliankin, Vitalii Tamargo, Javier A. Campa, Adriana Narasimhan, Giri Hernandez, Jacqueline Rodriguez, Jose A. Bastida Teeman, Colby Johnson, Angelique Sherman, Kenneth E. Baum, Marianna K. Metabolites Article The gut–liver axis has been recognized as a potential pathway in which dietary factors may contribute to liver disease in people living with HIV (PLWH). The objective of this study was to explore associations between dietary quality, the fecal microbiome, the metabolome, and liver health in PLWH from the Miami Adult Studies on HIV (MASH) cohort. We performed a cross-sectional analysis of 50 PLWH from the MASH cohort and utilized the USDA Healthy Eating Index (HEI)–2015 to measure diet quality. A Fibrosis-4 Index (FIB-4) score < 1.45 was used as a strong indication that advanced liver fibrosis was not present. Stool samples and fasting blood plasma samples were collected. Bacterial composition was characterized using 16S rRNA sequencing. Metabolomics in plasma were determined using gas and liquid chromatography/mass spectrometry. Statistical analyses included biomarker identification using linear discriminant analysis effect size. Compared to participants with FIB-4 ≥ 1.45, participants with FIB-4 < 1.45 had higher intake of dairy (p = 0.006). Fibrosis-4 Index score was inversely correlated with seafood and plant protein HEI component score (r = −0.320, p = 0.022). The relative abundances of butyrate-producing taxa Ruminococcaceae, Roseburia, and Lachnospiraceae were higher in participants with FIB-4 < 1.45. Participants with FIB-4 < 1.45 also had higher levels of caffeine (p = 0.045) and related metabolites such as trigonelline (p = 0.008) and 1-methylurate (p = 0.023). Dietary components appear to be associated with the fecal microbiome and metabolome, and liver health in PLWH. Future studies should investigate whether targeting specific dietary components may reduce liver-related morbidity and mortality in PLWH. MDPI 2023-02-14 /pmc/articles/PMC9962547/ /pubmed/36837890 http://dx.doi.org/10.3390/metabo13020271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martin, Haley R.
Sales Martinez, Sabrina
Stebliankin, Vitalii
Tamargo, Javier A.
Campa, Adriana
Narasimhan, Giri
Hernandez, Jacqueline
Rodriguez, Jose A. Bastida
Teeman, Colby
Johnson, Angelique
Sherman, Kenneth E.
Baum, Marianna K.
Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title_full Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title_fullStr Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title_full_unstemmed Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title_short Diet Quality and Liver Health in People Living with HIV in the MASH Cohort: A Multi-Omic Analysis of the Fecal Microbiome and Metabolome
title_sort diet quality and liver health in people living with hiv in the mash cohort: a multi-omic analysis of the fecal microbiome and metabolome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962547/
https://www.ncbi.nlm.nih.gov/pubmed/36837890
http://dx.doi.org/10.3390/metabo13020271
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