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High-frequency neuronal signal better explains multi-phase BOLD response

Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit more complex temporal dynamics than a simple monophasic response. For instance, BOLD responses sometimes include a phase of positive response followed by a phase of post-stimulus undershoot. Whether the BOLD response...

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Autores principales: Zhang, Qingqing, Cramer, Samuel R., Turner, Kevin L., Neuberger, Thomas, Drew, Patrick J., Zhang, Nanyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962576/
https://www.ncbi.nlm.nih.gov/pubmed/36681134
http://dx.doi.org/10.1016/j.neuroimage.2023.119887
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author Zhang, Qingqing
Cramer, Samuel R.
Turner, Kevin L.
Neuberger, Thomas
Drew, Patrick J.
Zhang, Nanyin
author_facet Zhang, Qingqing
Cramer, Samuel R.
Turner, Kevin L.
Neuberger, Thomas
Drew, Patrick J.
Zhang, Nanyin
author_sort Zhang, Qingqing
collection PubMed
description Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit more complex temporal dynamics than a simple monophasic response. For instance, BOLD responses sometimes include a phase of positive response followed by a phase of post-stimulus undershoot. Whether the BOLD response during these phases reflects the underlying neuronal signal fluctuations or is contributed by non-neuronal physiological factors remains elusive. When presenting blocks of sustained (i.e. DC) light ON-OFF stimulations to unanesthetized rats, we observed that the response following a decrease in illumination (i.e. OFF stimulation-evoked BOLD response) in the visual cortices displayed reproducible multiple phases, including an initial positive BOLD response, followed by an undershoot and then an overshoot before the next ON trial. This multi-phase BOLD response did not result from the entrainment of the periodic stimulation structure. When we measured the neural correlates of these responses, we found that the high-frequency band from the LFP power (300 – 3000 Hz, multi-unit activity (MUA)), but not the power in the gamma band (30 – 100 Hz) exhibited the same multiphasic dynamics as the BOLD signal. This study suggests that the post-stimulus phases of the BOLD response can be better explained by the high-frequency neuronal signal.
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spelling pubmed-99625762023-03-01 High-frequency neuronal signal better explains multi-phase BOLD response Zhang, Qingqing Cramer, Samuel R. Turner, Kevin L. Neuberger, Thomas Drew, Patrick J. Zhang, Nanyin Neuroimage Article Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit more complex temporal dynamics than a simple monophasic response. For instance, BOLD responses sometimes include a phase of positive response followed by a phase of post-stimulus undershoot. Whether the BOLD response during these phases reflects the underlying neuronal signal fluctuations or is contributed by non-neuronal physiological factors remains elusive. When presenting blocks of sustained (i.e. DC) light ON-OFF stimulations to unanesthetized rats, we observed that the response following a decrease in illumination (i.e. OFF stimulation-evoked BOLD response) in the visual cortices displayed reproducible multiple phases, including an initial positive BOLD response, followed by an undershoot and then an overshoot before the next ON trial. This multi-phase BOLD response did not result from the entrainment of the periodic stimulation structure. When we measured the neural correlates of these responses, we found that the high-frequency band from the LFP power (300 – 3000 Hz, multi-unit activity (MUA)), but not the power in the gamma band (30 – 100 Hz) exhibited the same multiphasic dynamics as the BOLD signal. This study suggests that the post-stimulus phases of the BOLD response can be better explained by the high-frequency neuronal signal. 2023-03 2023-01-18 /pmc/articles/PMC9962576/ /pubmed/36681134 http://dx.doi.org/10.1016/j.neuroimage.2023.119887 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Zhang, Qingqing
Cramer, Samuel R.
Turner, Kevin L.
Neuberger, Thomas
Drew, Patrick J.
Zhang, Nanyin
High-frequency neuronal signal better explains multi-phase BOLD response
title High-frequency neuronal signal better explains multi-phase BOLD response
title_full High-frequency neuronal signal better explains multi-phase BOLD response
title_fullStr High-frequency neuronal signal better explains multi-phase BOLD response
title_full_unstemmed High-frequency neuronal signal better explains multi-phase BOLD response
title_short High-frequency neuronal signal better explains multi-phase BOLD response
title_sort high-frequency neuronal signal better explains multi-phase bold response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962576/
https://www.ncbi.nlm.nih.gov/pubmed/36681134
http://dx.doi.org/10.1016/j.neuroimage.2023.119887
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