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Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study

Background: In contrast to studies in patients, an association between obesity and blood coagulation factors has not been established in the population. If confirmed it could become a target for primary prevention. Objective: To investigate the relationship between Body Mass Index (BMI) and waist ci...

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Autores principales: Iglesias Morcillo, Maximilian, Freuer, Dennis, Peters, Annette, Heier, Margit, Meisinger, Christine, Linseisen, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962601/
https://www.ncbi.nlm.nih.gov/pubmed/36837430
http://dx.doi.org/10.3390/medicina59020228
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author Iglesias Morcillo, Maximilian
Freuer, Dennis
Peters, Annette
Heier, Margit
Meisinger, Christine
Linseisen, Jakob
author_facet Iglesias Morcillo, Maximilian
Freuer, Dennis
Peters, Annette
Heier, Margit
Meisinger, Christine
Linseisen, Jakob
author_sort Iglesias Morcillo, Maximilian
collection PubMed
description Background: In contrast to studies in patients, an association between obesity and blood coagulation factors has not been established in the population. If confirmed it could become a target for primary prevention. Objective: To investigate the relationship between Body Mass Index (BMI) and waist circumference (WC) with plasma concentrations of antithrombin III, D-dimers, fibrinogen D, protein S, factor VIII, activated partial thromboplastin time (aPTT), quick value, and international normalized ratio (INR) in the general population. Materials and Methods: Participants of the Cooperative Health Research in the Region of Augsburg (KORA) S4 study who took part in the KORA Fit follow-up (2018–2019, aged 54–74 years) examination were eligible. Citrate plasma samples were collected in fasted participants. After the exclusion of participants with anticoagulative treatment, 776 participants (420 women and 356 men) with analytic data on hemostatic factors were included in the present analysis. Linear regression models were used to explore the association between BMI or WC with hemostatic markers, adjusted for sex, age, alcohol consumption, education, smoking status, and physical activity. In a second model, additional adjustments were made for the prevalence of stroke, hypertension, myocardial infarction, serum non-HDL cholesterol, and serum triglycerides. Results: In the multivariable models (with or without health conditions), significant positive associations with BMI were obtained for plasma concentrations of D-dimers, factor VIII, fibrinogen D, protein S, and quick value, while INR and antithrombin III were inversely associated. Similar to BMI, WC was significantly associated with all hemostatic factors, except for aPTT. Conclusion: In this population-based study, both increasing BMI and WC affect the blood coagulation system. Thus, modification of a prothrombotic coagulation profile emerged as a potential target for primary prevention in obese subjects.
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spelling pubmed-99626012023-02-26 Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study Iglesias Morcillo, Maximilian Freuer, Dennis Peters, Annette Heier, Margit Meisinger, Christine Linseisen, Jakob Medicina (Kaunas) Article Background: In contrast to studies in patients, an association between obesity and blood coagulation factors has not been established in the population. If confirmed it could become a target for primary prevention. Objective: To investigate the relationship between Body Mass Index (BMI) and waist circumference (WC) with plasma concentrations of antithrombin III, D-dimers, fibrinogen D, protein S, factor VIII, activated partial thromboplastin time (aPTT), quick value, and international normalized ratio (INR) in the general population. Materials and Methods: Participants of the Cooperative Health Research in the Region of Augsburg (KORA) S4 study who took part in the KORA Fit follow-up (2018–2019, aged 54–74 years) examination were eligible. Citrate plasma samples were collected in fasted participants. After the exclusion of participants with anticoagulative treatment, 776 participants (420 women and 356 men) with analytic data on hemostatic factors were included in the present analysis. Linear regression models were used to explore the association between BMI or WC with hemostatic markers, adjusted for sex, age, alcohol consumption, education, smoking status, and physical activity. In a second model, additional adjustments were made for the prevalence of stroke, hypertension, myocardial infarction, serum non-HDL cholesterol, and serum triglycerides. Results: In the multivariable models (with or without health conditions), significant positive associations with BMI were obtained for plasma concentrations of D-dimers, factor VIII, fibrinogen D, protein S, and quick value, while INR and antithrombin III were inversely associated. Similar to BMI, WC was significantly associated with all hemostatic factors, except for aPTT. Conclusion: In this population-based study, both increasing BMI and WC affect the blood coagulation system. Thus, modification of a prothrombotic coagulation profile emerged as a potential target for primary prevention in obese subjects. MDPI 2023-01-26 /pmc/articles/PMC9962601/ /pubmed/36837430 http://dx.doi.org/10.3390/medicina59020228 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iglesias Morcillo, Maximilian
Freuer, Dennis
Peters, Annette
Heier, Margit
Meisinger, Christine
Linseisen, Jakob
Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title_full Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title_fullStr Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title_full_unstemmed Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title_short Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study
title_sort body mass index and waist circumference as determinants of hemostatic factors in participants of a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962601/
https://www.ncbi.nlm.nih.gov/pubmed/36837430
http://dx.doi.org/10.3390/medicina59020228
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