COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People

The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory...

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Detalles Bibliográficos
Autores principales: Kountouras, Jannis, Tzitiridou-Chatzopoulou, Maria, Papaefthymiou, Apostolis, Chatzopoulos, Dimitrios, Doulberis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962607/
https://www.ncbi.nlm.nih.gov/pubmed/36837403
http://dx.doi.org/10.3390/medicina59020202
Descripción
Sumario:The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.

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