COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People

The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory...

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Autores principales: Kountouras, Jannis, Tzitiridou-Chatzopoulou, Maria, Papaefthymiou, Apostolis, Chatzopoulos, Dimitrios, Doulberis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962607/
https://www.ncbi.nlm.nih.gov/pubmed/36837403
http://dx.doi.org/10.3390/medicina59020202
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author Kountouras, Jannis
Tzitiridou-Chatzopoulou, Maria
Papaefthymiou, Apostolis
Chatzopoulos, Dimitrios
Doulberis, Michael
author_facet Kountouras, Jannis
Tzitiridou-Chatzopoulou, Maria
Papaefthymiou, Apostolis
Chatzopoulos, Dimitrios
Doulberis, Michael
author_sort Kountouras, Jannis
collection PubMed
description The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.
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spelling pubmed-99626072023-02-26 COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People Kountouras, Jannis Tzitiridou-Chatzopoulou, Maria Papaefthymiou, Apostolis Chatzopoulos, Dimitrios Doulberis, Michael Medicina (Kaunas) Opinion The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials. MDPI 2023-01-19 /pmc/articles/PMC9962607/ /pubmed/36837403 http://dx.doi.org/10.3390/medicina59020202 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Kountouras, Jannis
Tzitiridou-Chatzopoulou, Maria
Papaefthymiou, Apostolis
Chatzopoulos, Dimitrios
Doulberis, Michael
COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title_full COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title_fullStr COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title_full_unstemmed COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title_short COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People
title_sort covid-19 mrna vaccine effectiveness against elderly frail people
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962607/
https://www.ncbi.nlm.nih.gov/pubmed/36837403
http://dx.doi.org/10.3390/medicina59020202
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