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Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil

Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Bra...

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Detalles Bibliográficos
Autores principales: de Menezes, Mariane Talon, Moreira, Filipe Romero Rebello, Whittaker, Charles, Santos, Franciele Martins, Queiroz, Daniel Costa, Geddes, Victor, Fonseca, Paula Luize Camargos, de Jesus, Jaqueline Góes, Mendes-Oliveira, Franciane, Reis-Souza, Valquíria, Santos, Bibiana, Zauli, Danielle Alves Gomes, de Lima, Aline Brito, de Brito Mendonça, Cristiane, Alvim, Luige Biciati, do Prado Silva, Joice, Malta, Frederico Scott Varella, de Souza Ferreira, Alessandro Clayton, Faria, Nuno R., Sabino, Ester Cerdeira, Aguiar, Renato Santana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962645/
https://www.ncbi.nlm.nih.gov/pubmed/36851799
http://dx.doi.org/10.3390/v15020585
Descripción
Sumario:Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.