Polyketides as Secondary Metabolites from the Genus Aspergillus

Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups. These compounds have attracted the worldwide attention of pharmaceutical researchers since they are endowed with a wide arra...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Xuelian, Sheng, Yue, Tang, Zhenxing, Pan, Jingyi, Wang, Shigui, Tang, Bin, Zhou, Ting, Shi, Lu’e, Zhang, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962652/
https://www.ncbi.nlm.nih.gov/pubmed/36836375
http://dx.doi.org/10.3390/jof9020261
_version_ 1784896058651836416
author Bai, Xuelian
Sheng, Yue
Tang, Zhenxing
Pan, Jingyi
Wang, Shigui
Tang, Bin
Zhou, Ting
Shi, Lu’e
Zhang, Huawei
author_facet Bai, Xuelian
Sheng, Yue
Tang, Zhenxing
Pan, Jingyi
Wang, Shigui
Tang, Bin
Zhou, Ting
Shi, Lu’e
Zhang, Huawei
author_sort Bai, Xuelian
collection PubMed
description Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups. These compounds have attracted the worldwide attention of pharmaceutical researchers since they are endowed with a wide array of biological properties. As one of the most common filamentous fungi in nature, Aspergillus spp. is well known as an excellent producer of polyketide compounds with therapeutic potential. By extensive literature search and data analysis, this review comprehensively summarizes Aspergillus-derived polyketides for the first time, regarding their occurrences, chemical structures and bioactivities as well as biosynthetic logics.
format Online
Article
Text
id pubmed-9962652
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99626522023-02-26 Polyketides as Secondary Metabolites from the Genus Aspergillus Bai, Xuelian Sheng, Yue Tang, Zhenxing Pan, Jingyi Wang, Shigui Tang, Bin Zhou, Ting Shi, Lu’e Zhang, Huawei J Fungi (Basel) Review Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups. These compounds have attracted the worldwide attention of pharmaceutical researchers since they are endowed with a wide array of biological properties. As one of the most common filamentous fungi in nature, Aspergillus spp. is well known as an excellent producer of polyketide compounds with therapeutic potential. By extensive literature search and data analysis, this review comprehensively summarizes Aspergillus-derived polyketides for the first time, regarding their occurrences, chemical structures and bioactivities as well as biosynthetic logics. MDPI 2023-02-15 /pmc/articles/PMC9962652/ /pubmed/36836375 http://dx.doi.org/10.3390/jof9020261 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bai, Xuelian
Sheng, Yue
Tang, Zhenxing
Pan, Jingyi
Wang, Shigui
Tang, Bin
Zhou, Ting
Shi, Lu’e
Zhang, Huawei
Polyketides as Secondary Metabolites from the Genus Aspergillus
title Polyketides as Secondary Metabolites from the Genus Aspergillus
title_full Polyketides as Secondary Metabolites from the Genus Aspergillus
title_fullStr Polyketides as Secondary Metabolites from the Genus Aspergillus
title_full_unstemmed Polyketides as Secondary Metabolites from the Genus Aspergillus
title_short Polyketides as Secondary Metabolites from the Genus Aspergillus
title_sort polyketides as secondary metabolites from the genus aspergillus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962652/
https://www.ncbi.nlm.nih.gov/pubmed/36836375
http://dx.doi.org/10.3390/jof9020261
work_keys_str_mv AT baixuelian polyketidesassecondarymetabolitesfromthegenusaspergillus
AT shengyue polyketidesassecondarymetabolitesfromthegenusaspergillus
AT tangzhenxing polyketidesassecondarymetabolitesfromthegenusaspergillus
AT panjingyi polyketidesassecondarymetabolitesfromthegenusaspergillus
AT wangshigui polyketidesassecondarymetabolitesfromthegenusaspergillus
AT tangbin polyketidesassecondarymetabolitesfromthegenusaspergillus
AT zhouting polyketidesassecondarymetabolitesfromthegenusaspergillus
AT shilue polyketidesassecondarymetabolitesfromthegenusaspergillus
AT zhanghuawei polyketidesassecondarymetabolitesfromthegenusaspergillus

Ejemplares similares