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Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury

Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea,...

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Autores principales: Ryu, Jin Suk, Kim, So Yeon, Kim, Mee Kum, Oh, Joo Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962668/
https://www.ncbi.nlm.nih.gov/pubmed/36834749
http://dx.doi.org/10.3390/ijms24043329
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author Ryu, Jin Suk
Kim, So Yeon
Kim, Mee Kum
Oh, Joo Youn
author_facet Ryu, Jin Suk
Kim, So Yeon
Kim, Mee Kum
Oh, Joo Youn
author_sort Ryu, Jin Suk
collection PubMed
description Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, is the frontline barrier for the eye and is maintained by epithelial stem/progenitor cells in the limbus. Herein, we provide evidence that inflammatory memory also exists in the cornea. In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the cornea and lower levels of inflammatory cytokines following subsequent injury (either the same or a different type of injury) relative to naïve eyes without previous injury. In ocular Sjögren’s syndrome patients, corneal punctate epithelial erosions were significantly reduced after experiencing infectious injury compared with before. These results demonstrate that previous exposure of the corneal epithelium to inflammatory stimuli enhances corneal wound healing in response to a secondary assault, a phenomenon which points to the presence of nonspecific inflammatory memory in the cornea.
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spelling pubmed-99626682023-02-26 Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury Ryu, Jin Suk Kim, So Yeon Kim, Mee Kum Oh, Joo Youn Int J Mol Sci Article Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, is the frontline barrier for the eye and is maintained by epithelial stem/progenitor cells in the limbus. Herein, we provide evidence that inflammatory memory also exists in the cornea. In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the cornea and lower levels of inflammatory cytokines following subsequent injury (either the same or a different type of injury) relative to naïve eyes without previous injury. In ocular Sjögren’s syndrome patients, corneal punctate epithelial erosions were significantly reduced after experiencing infectious injury compared with before. These results demonstrate that previous exposure of the corneal epithelium to inflammatory stimuli enhances corneal wound healing in response to a secondary assault, a phenomenon which points to the presence of nonspecific inflammatory memory in the cornea. MDPI 2023-02-07 /pmc/articles/PMC9962668/ /pubmed/36834749 http://dx.doi.org/10.3390/ijms24043329 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ryu, Jin Suk
Kim, So Yeon
Kim, Mee Kum
Oh, Joo Youn
Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title_full Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title_fullStr Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title_full_unstemmed Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title_short Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
title_sort inflammation confers healing advantage to corneal epithelium following subsequent injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962668/
https://www.ncbi.nlm.nih.gov/pubmed/36834749
http://dx.doi.org/10.3390/ijms24043329
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