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Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland

Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larval form of Echinococcus multilocularis. In humans, it may become a serious chronic infection of the liver which resembles a slow malignant process leading to death when untreated. The aim of the study was an assessment of t...

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Autores principales: Stefaniak, Magdalena, Derda, Monika, Zmora, Pawel, Nowak, Szymon Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962699/
https://www.ncbi.nlm.nih.gov/pubmed/36839470
http://dx.doi.org/10.3390/pathogens12020199
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author Stefaniak, Magdalena
Derda, Monika
Zmora, Pawel
Nowak, Szymon Pawel
author_facet Stefaniak, Magdalena
Derda, Monika
Zmora, Pawel
Nowak, Szymon Pawel
author_sort Stefaniak, Magdalena
collection PubMed
description Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larval form of Echinococcus multilocularis. In humans, it may become a serious chronic infection of the liver which resembles a slow malignant process leading to death when untreated. The aim of the study was an assessment of the risk factors of the E. multilocularis infections and the description of AE clinical course in the group of 36 patients with confirmed AE, hospitalized at the Department and Clinic of Tropical and Parasitic Diseases, Poznan University of Medical Sciences between 2013 and 2022. Among the study participants, most patients cultivated land, bred livestock, worked in the forest, or were employed in animal shelters. The E. multilocularis infection was diagnosed based on imaging and immunoassay techniques within 6 months in the majority of patients hospitalized in the Department. All patients hospitalized in the Department initiated anti-parasitic therapy at the moment of the diagnosis. Pharmacological treatment combined with surgery was applied in most of the study participants, who were presented with more advanced stages of infection. We conclude the following: 1. For humans in the risk group, regular abdominal imaging examinations and the detection of specific antibodies against E. multilocularis are recommended. 2. Regular screening tests in the hyperendemic areas of AE would increase the early detection of the disease and to improve the clinical prognosis in this extremely life-threatening parasitic disease.
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spelling pubmed-99626992023-02-26 Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland Stefaniak, Magdalena Derda, Monika Zmora, Pawel Nowak, Szymon Pawel Pathogens Article Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larval form of Echinococcus multilocularis. In humans, it may become a serious chronic infection of the liver which resembles a slow malignant process leading to death when untreated. The aim of the study was an assessment of the risk factors of the E. multilocularis infections and the description of AE clinical course in the group of 36 patients with confirmed AE, hospitalized at the Department and Clinic of Tropical and Parasitic Diseases, Poznan University of Medical Sciences between 2013 and 2022. Among the study participants, most patients cultivated land, bred livestock, worked in the forest, or were employed in animal shelters. The E. multilocularis infection was diagnosed based on imaging and immunoassay techniques within 6 months in the majority of patients hospitalized in the Department. All patients hospitalized in the Department initiated anti-parasitic therapy at the moment of the diagnosis. Pharmacological treatment combined with surgery was applied in most of the study participants, who were presented with more advanced stages of infection. We conclude the following: 1. For humans in the risk group, regular abdominal imaging examinations and the detection of specific antibodies against E. multilocularis are recommended. 2. Regular screening tests in the hyperendemic areas of AE would increase the early detection of the disease and to improve the clinical prognosis in this extremely life-threatening parasitic disease. MDPI 2023-01-28 /pmc/articles/PMC9962699/ /pubmed/36839470 http://dx.doi.org/10.3390/pathogens12020199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stefaniak, Magdalena
Derda, Monika
Zmora, Pawel
Nowak, Szymon Pawel
Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title_full Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title_fullStr Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title_full_unstemmed Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title_short Risk Factors and the Character of Clinical Course of the Echinococcus multilocularis Infection in Patients in Poland
title_sort risk factors and the character of clinical course of the echinococcus multilocularis infection in patients in poland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962699/
https://www.ncbi.nlm.nih.gov/pubmed/36839470
http://dx.doi.org/10.3390/pathogens12020199
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