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Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features
Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962715/ https://www.ncbi.nlm.nih.gov/pubmed/36836214 http://dx.doi.org/10.3390/jcm12041678 |
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author | Khashchenko, Elena P. Uvarova, Elena V. Fatkhudinov, Timur Kh. Chuprynin, Vladimir D. Asaturova, Aleksandra V. Kulabukhova, Elena A. Vysokikh, Mikhail Yu. Allakhverdieva, Elvina Z. Alekseeva, Maria N. Adamyan, Leila V. Sukhikh, Gennady T. |
author_facet | Khashchenko, Elena P. Uvarova, Elena V. Fatkhudinov, Timur Kh. Chuprynin, Vladimir D. Asaturova, Aleksandra V. Kulabukhova, Elena A. Vysokikh, Mikhail Yu. Allakhverdieva, Elvina Z. Alekseeva, Maria N. Adamyan, Leila V. Sukhikh, Gennady T. |
author_sort | Khashchenko, Elena P. |
collection | PubMed |
description | Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to 17 years old) were included in a case–control study: 90 with laparoscopically (LS) confirmed PE, 44 healthy controls underwent full examination and LS was analyzed in the PE group. Results: Patients with PE were characterized with heredity for endometriosis, persistent dysmenorrhea, decreased daily activity, gastrointestinal symptoms, higher LH, estradiol, prolactin and Ca-125 (<0.05 for each). Ultrasound detected PE in 3.3% and MRI in 78.9%. The most essential MRI signs are as follows: hypointense foci, the heterogeneity of the pelvic tissue (paraovarian, parametrial and rectouterine pouch) and sacro-uterine ligaments lesions (<0.05 for each). Adolescents with PE mostly exhibit initial rASRM stages. Red implants correlated with the rASRM score, and sheer implants correlated with pain (VAS score) (<0.05). In 32.2%, foci consisted of fibrous, adipose and muscle tissue; black lesions were more likely to be histologically verified (0.001). Conclusion: Adolescents exhibit mostly initial PE stages, which are associated with greater pain. Persistent dysmenorrhea and detected MRI parameters predict the laparoscopic confirmation of initial PE in adolescents in 84.3% (OR 15.4; <0.01), justifying the early surgical diagnostics and shortening the time delay and suffering of the young patients. |
format | Online Article Text |
id | pubmed-9962715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99627152023-02-26 Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features Khashchenko, Elena P. Uvarova, Elena V. Fatkhudinov, Timur Kh. Chuprynin, Vladimir D. Asaturova, Aleksandra V. Kulabukhova, Elena A. Vysokikh, Mikhail Yu. Allakhverdieva, Elvina Z. Alekseeva, Maria N. Adamyan, Leila V. Sukhikh, Gennady T. J Clin Med Article Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to 17 years old) were included in a case–control study: 90 with laparoscopically (LS) confirmed PE, 44 healthy controls underwent full examination and LS was analyzed in the PE group. Results: Patients with PE were characterized with heredity for endometriosis, persistent dysmenorrhea, decreased daily activity, gastrointestinal symptoms, higher LH, estradiol, prolactin and Ca-125 (<0.05 for each). Ultrasound detected PE in 3.3% and MRI in 78.9%. The most essential MRI signs are as follows: hypointense foci, the heterogeneity of the pelvic tissue (paraovarian, parametrial and rectouterine pouch) and sacro-uterine ligaments lesions (<0.05 for each). Adolescents with PE mostly exhibit initial rASRM stages. Red implants correlated with the rASRM score, and sheer implants correlated with pain (VAS score) (<0.05). In 32.2%, foci consisted of fibrous, adipose and muscle tissue; black lesions were more likely to be histologically verified (0.001). Conclusion: Adolescents exhibit mostly initial PE stages, which are associated with greater pain. Persistent dysmenorrhea and detected MRI parameters predict the laparoscopic confirmation of initial PE in adolescents in 84.3% (OR 15.4; <0.01), justifying the early surgical diagnostics and shortening the time delay and suffering of the young patients. MDPI 2023-02-20 /pmc/articles/PMC9962715/ /pubmed/36836214 http://dx.doi.org/10.3390/jcm12041678 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khashchenko, Elena P. Uvarova, Elena V. Fatkhudinov, Timur Kh. Chuprynin, Vladimir D. Asaturova, Aleksandra V. Kulabukhova, Elena A. Vysokikh, Mikhail Yu. Allakhverdieva, Elvina Z. Alekseeva, Maria N. Adamyan, Leila V. Sukhikh, Gennady T. Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title | Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title_full | Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title_fullStr | Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title_full_unstemmed | Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title_short | Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features |
title_sort | endometriosis in adolescents: diagnostics, clinical and laparoscopic features |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962715/ https://www.ncbi.nlm.nih.gov/pubmed/36836214 http://dx.doi.org/10.3390/jcm12041678 |
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