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Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD

The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse...

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Autores principales: de Andrade Gandolfi, Flora, Estofolete, Cassia Fernanda, Wakai, Marcia Catelan, Negri, Andreia Francesli, Barcelos, Michela Dias, Vasilakis, Nikos, Nogueira, Mauricio Lacerda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962731/
https://www.ncbi.nlm.nih.gov/pubmed/36851322
http://dx.doi.org/10.3390/vaccines11020445
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author de Andrade Gandolfi, Flora
Estofolete, Cassia Fernanda
Wakai, Marcia Catelan
Negri, Andreia Francesli
Barcelos, Michela Dias
Vasilakis, Nikos
Nogueira, Mauricio Lacerda
author_facet de Andrade Gandolfi, Flora
Estofolete, Cassia Fernanda
Wakai, Marcia Catelan
Negri, Andreia Francesli
Barcelos, Michela Dias
Vasilakis, Nikos
Nogueira, Mauricio Lacerda
author_sort de Andrade Gandolfi, Flora
collection PubMed
description The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner.
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spelling pubmed-99627312023-02-26 Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD de Andrade Gandolfi, Flora Estofolete, Cassia Fernanda Wakai, Marcia Catelan Negri, Andreia Francesli Barcelos, Michela Dias Vasilakis, Nikos Nogueira, Mauricio Lacerda Vaccines (Basel) Case Report The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner. MDPI 2023-02-15 /pmc/articles/PMC9962731/ /pubmed/36851322 http://dx.doi.org/10.3390/vaccines11020445 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
de Andrade Gandolfi, Flora
Estofolete, Cassia Fernanda
Wakai, Marcia Catelan
Negri, Andreia Francesli
Barcelos, Michela Dias
Vasilakis, Nikos
Nogueira, Mauricio Lacerda
Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title_full Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title_fullStr Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title_full_unstemmed Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title_short Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD
title_sort yellow fever vaccine-related neurotropic disease in brazil following immunization with 17dd
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962731/
https://www.ncbi.nlm.nih.gov/pubmed/36851322
http://dx.doi.org/10.3390/vaccines11020445
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