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Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice

With the extension of the human life span and the increasing pressure of women’s work and life, menopause syndrome (MPS) refers to a problem that puzzles almost all women worldwide. Hormone replacement treatment (HRT) can effectively mitigate the symptoms but can also exert adverse effects to a cert...

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Autores principales: Zhang, Ying, Chen, Yumin, Bai, Xue, Cheng, Guoliang, Cao, Tianyou, Dong, Liyang, Zhao, Jie, Zhang, Yue, Qu, Huihua, Kong, Hui, Zhao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962818/
https://www.ncbi.nlm.nih.gov/pubmed/36838814
http://dx.doi.org/10.3390/molecules28041830
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author Zhang, Ying
Chen, Yumin
Bai, Xue
Cheng, Guoliang
Cao, Tianyou
Dong, Liyang
Zhao, Jie
Zhang, Yue
Qu, Huihua
Kong, Hui
Zhao, Yan
author_facet Zhang, Ying
Chen, Yumin
Bai, Xue
Cheng, Guoliang
Cao, Tianyou
Dong, Liyang
Zhao, Jie
Zhang, Yue
Qu, Huihua
Kong, Hui
Zhao, Yan
author_sort Zhang, Ying
collection PubMed
description With the extension of the human life span and the increasing pressure of women’s work and life, menopause syndrome (MPS) refers to a problem that puzzles almost all women worldwide. Hormone replacement treatment (HRT) can effectively mitigate the symptoms but can also exert adverse effects to a certain extent. Glycyrrhizae radix et rhizome (GRR) is commonly made into a charcoal processed product, termed GRR Carbonisatas (GRRC), for use in traditional Chinese medicine (TCM). GRRC is widely used to treat MPS and other gynecological diseases. In this study, GRRC was prepared through pyrolysis. Subsequently, GRR-derived carbon dots (GRR-CDs) were purified through dialysis and characterized using transmission electron microscopy, high-resolution transmission electron microscopy, Fourier-transform infrared, ultraviolet, fluorescence, X-ray photoelectron microscopy, and high-performance liquid chromatography. The effects of GRR-CDs on MPS were examined and confirmed using ovariectomized female mice models. The GRR-CDs ranged from 1.0 to 3.0 nm in diameter and with multiple surface chemical groups, as indicated by the results. GRR-CDs can elevate the estradiol (E2) level of healthy female mice. Moreover, GRR-CDs can alleviate MPS using the typical ovariectomized mice model, as confirmed by elevating the estradiol (E2) level and reducing the degree of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and raising the degree of uterine atrophy. The results of this study suggested that GRR-CDs may be a potential clinical candidate for the treatment of MPS, which also provides a possibility for nanodrugs to treat hormonal diseases.
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spelling pubmed-99628182023-02-26 Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice Zhang, Ying Chen, Yumin Bai, Xue Cheng, Guoliang Cao, Tianyou Dong, Liyang Zhao, Jie Zhang, Yue Qu, Huihua Kong, Hui Zhao, Yan Molecules Article With the extension of the human life span and the increasing pressure of women’s work and life, menopause syndrome (MPS) refers to a problem that puzzles almost all women worldwide. Hormone replacement treatment (HRT) can effectively mitigate the symptoms but can also exert adverse effects to a certain extent. Glycyrrhizae radix et rhizome (GRR) is commonly made into a charcoal processed product, termed GRR Carbonisatas (GRRC), for use in traditional Chinese medicine (TCM). GRRC is widely used to treat MPS and other gynecological diseases. In this study, GRRC was prepared through pyrolysis. Subsequently, GRR-derived carbon dots (GRR-CDs) were purified through dialysis and characterized using transmission electron microscopy, high-resolution transmission electron microscopy, Fourier-transform infrared, ultraviolet, fluorescence, X-ray photoelectron microscopy, and high-performance liquid chromatography. The effects of GRR-CDs on MPS were examined and confirmed using ovariectomized female mice models. The GRR-CDs ranged from 1.0 to 3.0 nm in diameter and with multiple surface chemical groups, as indicated by the results. GRR-CDs can elevate the estradiol (E2) level of healthy female mice. Moreover, GRR-CDs can alleviate MPS using the typical ovariectomized mice model, as confirmed by elevating the estradiol (E2) level and reducing the degree of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and raising the degree of uterine atrophy. The results of this study suggested that GRR-CDs may be a potential clinical candidate for the treatment of MPS, which also provides a possibility for nanodrugs to treat hormonal diseases. MDPI 2023-02-15 /pmc/articles/PMC9962818/ /pubmed/36838814 http://dx.doi.org/10.3390/molecules28041830 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Ying
Chen, Yumin
Bai, Xue
Cheng, Guoliang
Cao, Tianyou
Dong, Liyang
Zhao, Jie
Zhang, Yue
Qu, Huihua
Kong, Hui
Zhao, Yan
Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title_full Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title_fullStr Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title_full_unstemmed Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title_short Glycyrrhizae radix et Rhizoma-Derived Carbon Dots and Their Effect on Menopause Syndrome in Ovariectomized Mice
title_sort glycyrrhizae radix et rhizoma-derived carbon dots and their effect on menopause syndrome in ovariectomized mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962818/
https://www.ncbi.nlm.nih.gov/pubmed/36838814
http://dx.doi.org/10.3390/molecules28041830
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