Cargando…

Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels

This study reports results of a mechanical platform-based screening assay (MICA) to evaluate the remote activation of mechanosensitive ion channels. Here, we studied ERK pathway activation and the elevation in intracellular Ca(2+) levels in response to the MICA application using the Luciferase assay...

Descripción completa

Detalles Bibliográficos
Autores principales:	Unnithan, Afeesh Rajan, Rotherham, Michael, Markides, Hareklea, El Haj, Alicia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962865/ https://www.ncbi.nlm.nih.gov/pubmed/36834776 http://dx.doi.org/10.3390/ijms24043364

Ejemplares similares

Selective activation of mechanosensitive ion channels using magnetic particles
por: Hughes, Steven, et al.
Publicado: (2007)

Mechanosensitive Ion Channels in Cardiovascular Physiology
por: Teng, Jinfeng, et al.
Publicado: (2014)

Mechanosensitive ion channels in cell migration
por: Canales Coutiño, Brenda, et al.
Publicado: (2021)

Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells
por: Henstock, James R, et al.
Publicado: (2018)

The role of mechanosensitive ion channels in the gastrointestinal tract
por: Yang, Haoyu, et al.
Publicado: (2022)

Mechanosensitive Ion Channels and Their Role in Cancer Cells
por: Karska, Julia, et al.
Publicado: (2023)

Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
por: Kapsalis, Charalampos, et al.
Publicado: (2019)

Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts
por: Stewart, Leander, et al.
Publicado: (2021)

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier
por: Brohawn, Stephen G, et al.
Publicado: (2019)

Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels
por: Pérez-Mitta, Gonzalo, et al.
Publicado: (2023)

Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future
por: Song, Mengyao, et al.
Publicado: (2023)

The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
por: Zhu, Jiejun, et al.
Publicado: (2023)

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
por: Adapala, Ravi K., et al.
Publicado: (2015)

Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers
por: Rosholm, Kadla R., et al.
Publicado: (2017)

The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments
por: Lee, Hong-pyo, et al.
Publicado: (2021)

Connection between Oligomeric State and Gating Characteristics of Mechanosensitive Ion Channels
por: Haselwandter, Christoph A., et al.
Publicado: (2013)

Mechanosensitive ion channels: An evolutionary and scientific tour de force in mechanobiology
por: Martinac, Boris
Publicado: (2012)

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1
por: Lawrence, K. M., et al.
Publicado: (2017)

Expression and function of mechanosensitive ion channels in human valve interstitial cells
por: Al-Shammari, Hessah, et al.
Publicado: (2020)

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC
por: Wang, Yang, et al.
Publicado: (2021)

Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1
por: Jojoa-Cruz, Sebastian, et al.
Publicado: (2022)

206 The Role of Mechanosensitive Ion Channels in Primary Open Angle Glaucoma
por: Liu, Wendy, et al.
Publicado: (2022)

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis
por: Bera, Kaustav, et al.
Publicado: (2022)

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
por: Wang, Yuexin, et al.
Publicado: (2022)

Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel
por: Mount, Jonathan, et al.
Publicado: (2022)

Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1
por: Kim, Yong-Jae, et al.
Publicado: (2023)

Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10
por: Zhang, Jingying, et al.
Publicado: (2023)

Mutational analysis of mechanosensitive ion channels in the carnivorous Venus flytrap plant
por: Procko, Carl, et al.
Publicado: (2023)

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
por: Otero-Sobrino, Álvaro, et al.
Publicado: (2023)

Activation of the Mechanosensitive Ion Channels Piezo1 and TRPV4 in Primary Human Healthy and Osteoarthritic Chondrocytes Exhibits Ion Channel Crosstalk and Modulates Gene Expression
por: Steinecker-Frohnwieser, Bibiane, et al.
Publicado: (2023)

Formation and Function of Mammalian Epithelia: Roles for Mechanosensitive PIEZO1 Ion Channels
por: Stewart, Teneale A., et al.
Publicado: (2019)

OzTracs: Optical Osmolality Reporters Engineered from Mechanosensitive Ion Channels
por: Kleist, Thomas J., et al.
Publicado: (2022)

Drosophila ppk19 encodes a proton-gated and mechanosensitive ion channel
por: Jang, Wijeong, et al.
Publicado: (2022)

The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
por: Zhu, Ting, et al.
Publicado: (2023)

Charged pore-lining residues are required for normal channel kinetics in the eukaryotic mechanosensitive ion channel MSL1
por: Schlegel, Angela M., et al.
Publicado: (2020)

Nanometer collimation enhancement of ion beams using channeling effects in track-etched mica capillaries
por: Scheuner, Clemens, et al.
Publicado: (2017)

Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics
Publicado: (1996)

Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity
por: Moshourab, Rabih A, et al.
Publicado: (2013)

The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels
por: Bavi, Omid, et al.
Publicado: (2016)

In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions
por: Dimitrova, Anna, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0q8g4cc5fc834f7uoedrgv4p08