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Hyperinflammatory Response in COVID-19: A Systematic Review

COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathologic...

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Autores principales: Silva, Marcos Jessé Abrahão, Ribeiro, Layana Rufino, Gouveia, Maria Isabel Montoril, Marcelino, Beatriz dos Reis, dos Santos, Carolynne Silva, Lima, Karla Valéria Batista, Lima, Luana Nepomuceno Gondim Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962879/
https://www.ncbi.nlm.nih.gov/pubmed/36851766
http://dx.doi.org/10.3390/v15020553
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author Silva, Marcos Jessé Abrahão
Ribeiro, Layana Rufino
Gouveia, Maria Isabel Montoril
Marcelino, Beatriz dos Reis
dos Santos, Carolynne Silva
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author_facet Silva, Marcos Jessé Abrahão
Ribeiro, Layana Rufino
Gouveia, Maria Isabel Montoril
Marcelino, Beatriz dos Reis
dos Santos, Carolynne Silva
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
author_sort Silva, Marcos Jessé Abrahão
collection PubMed
description COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathological elements that contribute to its progression. This is a systematic review using the PUBMED, LILACS, MEDLINE, and SCIELO databases using articles between May 2020 and July 2022 with the following search terms in conjunction with “AND”: “SARS-CoV-2”; “COVID-19”; “ARDS” and “Cytokine Storm”. The quality appraisal and risk of bias were assessed by the JBI checklists and the Cochrane Collaboration’s RoB 2.0 and ROBINS-I tools, respectively, and the risk of bias for in vitro studies by a pre-defined standard in the literature. The search resulted in 39 articles. The main actors in this response denote SARS-CoV-2 Spike proteins, cellular proteases, leukocytes, cytokines, and proteolytic cascades. The “cytokine storm” itself brings several complications to the host through cytokines such as IL-6 and chemokines (such as CCL2), which influence tissue inflammation through apoptosis and pyroptosis. The hyperinflammatory response causes several unfavorable outcomes in patients, and systemic inflammation caused largely by the dysregulation of the immune response should be controlled for their recovery.
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spelling pubmed-99628792023-02-26 Hyperinflammatory Response in COVID-19: A Systematic Review Silva, Marcos Jessé Abrahão Ribeiro, Layana Rufino Gouveia, Maria Isabel Montoril Marcelino, Beatriz dos Reis dos Santos, Carolynne Silva Lima, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa Viruses Review COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathological elements that contribute to its progression. This is a systematic review using the PUBMED, LILACS, MEDLINE, and SCIELO databases using articles between May 2020 and July 2022 with the following search terms in conjunction with “AND”: “SARS-CoV-2”; “COVID-19”; “ARDS” and “Cytokine Storm”. The quality appraisal and risk of bias were assessed by the JBI checklists and the Cochrane Collaboration’s RoB 2.0 and ROBINS-I tools, respectively, and the risk of bias for in vitro studies by a pre-defined standard in the literature. The search resulted in 39 articles. The main actors in this response denote SARS-CoV-2 Spike proteins, cellular proteases, leukocytes, cytokines, and proteolytic cascades. The “cytokine storm” itself brings several complications to the host through cytokines such as IL-6 and chemokines (such as CCL2), which influence tissue inflammation through apoptosis and pyroptosis. The hyperinflammatory response causes several unfavorable outcomes in patients, and systemic inflammation caused largely by the dysregulation of the immune response should be controlled for their recovery. MDPI 2023-02-16 /pmc/articles/PMC9962879/ /pubmed/36851766 http://dx.doi.org/10.3390/v15020553 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Silva, Marcos Jessé Abrahão
Ribeiro, Layana Rufino
Gouveia, Maria Isabel Montoril
Marcelino, Beatriz dos Reis
dos Santos, Carolynne Silva
Lima, Karla Valéria Batista
Lima, Luana Nepomuceno Gondim Costa
Hyperinflammatory Response in COVID-19: A Systematic Review
title Hyperinflammatory Response in COVID-19: A Systematic Review
title_full Hyperinflammatory Response in COVID-19: A Systematic Review
title_fullStr Hyperinflammatory Response in COVID-19: A Systematic Review
title_full_unstemmed Hyperinflammatory Response in COVID-19: A Systematic Review
title_short Hyperinflammatory Response in COVID-19: A Systematic Review
title_sort hyperinflammatory response in covid-19: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962879/
https://www.ncbi.nlm.nih.gov/pubmed/36851766
http://dx.doi.org/10.3390/v15020553
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