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Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
While important insights were gained about how FGF21 and other endocrine fibroblast growth factors (FGFs) bind to Klotho proteins, the exact mechanism of Klotho/FGF receptor assembly that drives receptor dimerization and activation has not been elucidated. The prevailing dogma is that Klotho protein...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962926/ https://www.ncbi.nlm.nih.gov/pubmed/36745784 http://dx.doi.org/10.1073/pnas.2219128120 |