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Tear Film MicroRNAs as Potential Biomarkers: A Review
MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962948/ https://www.ncbi.nlm.nih.gov/pubmed/36835108 http://dx.doi.org/10.3390/ijms24043694 |
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author | Altman, Jeremy Jones, Garrett Ahmed, Saleh Sharma, Shruti Sharma, Ashok |
author_facet | Altman, Jeremy Jones, Garrett Ahmed, Saleh Sharma, Shruti Sharma, Ashok |
author_sort | Altman, Jeremy |
collection | PubMed |
description | MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and pathophysiological states continue to expand. Advances in detection methods have further enabled larger adoption of studies utilizing minimal sample volumes, allowing the analysis of microRNAs in low-volume biofluids, such as the aqueous humor and tear fluid. The reported abundance of extracellular microRNAs in these biofluids has prompted studies to explore their biomarker potential. This review compiles the current literature reporting microRNAs in human tear fluid and their association with ocular diseases including dry eye disease, Sjögren’s syndrome, keratitis, vernal keratoconjunctivitis, glaucoma, diabetic macular edema, and diabetic retinopathy, as well as non-ocular diseases, including Alzheimer’s and breast cancer. We also summarize the known roles of these microRNAs and shed light on the future progression of this field. |
format | Online Article Text |
id | pubmed-9962948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99629482023-02-26 Tear Film MicroRNAs as Potential Biomarkers: A Review Altman, Jeremy Jones, Garrett Ahmed, Saleh Sharma, Shruti Sharma, Ashok Int J Mol Sci Review MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and pathophysiological states continue to expand. Advances in detection methods have further enabled larger adoption of studies utilizing minimal sample volumes, allowing the analysis of microRNAs in low-volume biofluids, such as the aqueous humor and tear fluid. The reported abundance of extracellular microRNAs in these biofluids has prompted studies to explore their biomarker potential. This review compiles the current literature reporting microRNAs in human tear fluid and their association with ocular diseases including dry eye disease, Sjögren’s syndrome, keratitis, vernal keratoconjunctivitis, glaucoma, diabetic macular edema, and diabetic retinopathy, as well as non-ocular diseases, including Alzheimer’s and breast cancer. We also summarize the known roles of these microRNAs and shed light on the future progression of this field. MDPI 2023-02-12 /pmc/articles/PMC9962948/ /pubmed/36835108 http://dx.doi.org/10.3390/ijms24043694 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Altman, Jeremy Jones, Garrett Ahmed, Saleh Sharma, Shruti Sharma, Ashok Tear Film MicroRNAs as Potential Biomarkers: A Review |
title | Tear Film MicroRNAs as Potential Biomarkers: A Review |
title_full | Tear Film MicroRNAs as Potential Biomarkers: A Review |
title_fullStr | Tear Film MicroRNAs as Potential Biomarkers: A Review |
title_full_unstemmed | Tear Film MicroRNAs as Potential Biomarkers: A Review |
title_short | Tear Film MicroRNAs as Potential Biomarkers: A Review |
title_sort | tear film micrornas as potential biomarkers: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962948/ https://www.ncbi.nlm.nih.gov/pubmed/36835108 http://dx.doi.org/10.3390/ijms24043694 |
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