Cargando…

Tear Film MicroRNAs as Potential Biomarkers: A Review

MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and...

Descripción completa

Detalles Bibliográficos
Autores principales: Altman, Jeremy, Jones, Garrett, Ahmed, Saleh, Sharma, Shruti, Sharma, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962948/
https://www.ncbi.nlm.nih.gov/pubmed/36835108
http://dx.doi.org/10.3390/ijms24043694
_version_ 1784896129120337920
author Altman, Jeremy
Jones, Garrett
Ahmed, Saleh
Sharma, Shruti
Sharma, Ashok
author_facet Altman, Jeremy
Jones, Garrett
Ahmed, Saleh
Sharma, Shruti
Sharma, Ashok
author_sort Altman, Jeremy
collection PubMed
description MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and pathophysiological states continue to expand. Advances in detection methods have further enabled larger adoption of studies utilizing minimal sample volumes, allowing the analysis of microRNAs in low-volume biofluids, such as the aqueous humor and tear fluid. The reported abundance of extracellular microRNAs in these biofluids has prompted studies to explore their biomarker potential. This review compiles the current literature reporting microRNAs in human tear fluid and their association with ocular diseases including dry eye disease, Sjögren’s syndrome, keratitis, vernal keratoconjunctivitis, glaucoma, diabetic macular edema, and diabetic retinopathy, as well as non-ocular diseases, including Alzheimer’s and breast cancer. We also summarize the known roles of these microRNAs and shed light on the future progression of this field.
format Online
Article
Text
id pubmed-9962948
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99629482023-02-26 Tear Film MicroRNAs as Potential Biomarkers: A Review Altman, Jeremy Jones, Garrett Ahmed, Saleh Sharma, Shruti Sharma, Ashok Int J Mol Sci Review MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of pathways such as inflammation, metabolism, homeostasis, cell machinery, and development. With the progression of sequencing methods and modern bioinformatics tools, novel roles of microRNAs in regulatory mechanisms and pathophysiological states continue to expand. Advances in detection methods have further enabled larger adoption of studies utilizing minimal sample volumes, allowing the analysis of microRNAs in low-volume biofluids, such as the aqueous humor and tear fluid. The reported abundance of extracellular microRNAs in these biofluids has prompted studies to explore their biomarker potential. This review compiles the current literature reporting microRNAs in human tear fluid and their association with ocular diseases including dry eye disease, Sjögren’s syndrome, keratitis, vernal keratoconjunctivitis, glaucoma, diabetic macular edema, and diabetic retinopathy, as well as non-ocular diseases, including Alzheimer’s and breast cancer. We also summarize the known roles of these microRNAs and shed light on the future progression of this field. MDPI 2023-02-12 /pmc/articles/PMC9962948/ /pubmed/36835108 http://dx.doi.org/10.3390/ijms24043694 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Altman, Jeremy
Jones, Garrett
Ahmed, Saleh
Sharma, Shruti
Sharma, Ashok
Tear Film MicroRNAs as Potential Biomarkers: A Review
title Tear Film MicroRNAs as Potential Biomarkers: A Review
title_full Tear Film MicroRNAs as Potential Biomarkers: A Review
title_fullStr Tear Film MicroRNAs as Potential Biomarkers: A Review
title_full_unstemmed Tear Film MicroRNAs as Potential Biomarkers: A Review
title_short Tear Film MicroRNAs as Potential Biomarkers: A Review
title_sort tear film micrornas as potential biomarkers: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962948/
https://www.ncbi.nlm.nih.gov/pubmed/36835108
http://dx.doi.org/10.3390/ijms24043694
work_keys_str_mv AT altmanjeremy tearfilmmicrornasaspotentialbiomarkersareview
AT jonesgarrett tearfilmmicrornasaspotentialbiomarkersareview
AT ahmedsaleh tearfilmmicrornasaspotentialbiomarkersareview
AT sharmashruti tearfilmmicrornasaspotentialbiomarkersareview
AT sharmaashok tearfilmmicrornasaspotentialbiomarkersareview