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Conformational rearrangements in the second voltage sensor domain switch PIP(2)- and voltage-gating modes in two-pore channels
Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP(2)) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC subtype achieves its unique preference. Here, we show that distinct conf...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963007/ https://www.ncbi.nlm.nih.gov/pubmed/36724253 http://dx.doi.org/10.1073/pnas.2209569120 |