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Generation and analysis of context-specific genome-scale metabolic models derived from single-cell RNA-Seq data
Single-cell RNA sequencing combined with genome-scale metabolic models (GEMs) has the potential to unravel the differences in metabolism across both cell types and cell states but requires new computational methods. Here, we present a method for generating cell-type-specific genome-scale models from...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963017/ https://www.ncbi.nlm.nih.gov/pubmed/36719923 http://dx.doi.org/10.1073/pnas.2217868120 |