Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance

Antigenic peptides derived from introns are presented on major histocompatibility (MHC) class I molecules, but how these peptides are produced is poorly understood. Here, we show that an MHC class I epitope (SL8) sequence inserted in the second intron of the β-globin gene in a C57BL/6 mouse (HBB) ge...

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Detalles Bibliográficos
Autores principales: Sroka, Ewa Maria, Lavigne, Mathilde, Pla, Marika, Daskalogianni, Chrysoula, Tovar-Fernandez, Maria Camila, Prado Martins, Rodrigo, Manoury, Bénédicte, Darrasse-Jéze, Guillaume, Nascimento, Megane, Apcher, Sebastien, Fåhraeus, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963070/
https://www.ncbi.nlm.nih.gov/pubmed/36745791
http://dx.doi.org/10.1073/pnas.2208509120

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