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The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints

MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from...

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Autores principales: Stella, Giulia M., Marchiò, Caterina, Bari, Elia, Ferrarotti, Ilaria, Bertuccio, Francesco R., Di Gennaro, Antonella, Abbott, David Michael, Putignano, Paola, Campo, Ilaria, Torre, Maria Luisa, Corsico, Angelo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963101/
https://www.ncbi.nlm.nih.gov/pubmed/36834912
http://dx.doi.org/10.3390/ijms24043496
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author Stella, Giulia M.
Marchiò, Caterina
Bari, Elia
Ferrarotti, Ilaria
Bertuccio, Francesco R.
Di Gennaro, Antonella
Abbott, David Michael
Putignano, Paola
Campo, Ilaria
Torre, Maria Luisa
Corsico, Angelo G.
author_facet Stella, Giulia M.
Marchiò, Caterina
Bari, Elia
Ferrarotti, Ilaria
Bertuccio, Francesco R.
Di Gennaro, Antonella
Abbott, David Michael
Putignano, Paola
Campo, Ilaria
Torre, Maria Luisa
Corsico, Angelo G.
author_sort Stella, Giulia M.
collection PubMed
description MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets.
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spelling pubmed-99631012023-02-26 The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints Stella, Giulia M. Marchiò, Caterina Bari, Elia Ferrarotti, Ilaria Bertuccio, Francesco R. Di Gennaro, Antonella Abbott, David Michael Putignano, Paola Campo, Ilaria Torre, Maria Luisa Corsico, Angelo G. Int J Mol Sci Review MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets. MDPI 2023-02-09 /pmc/articles/PMC9963101/ /pubmed/36834912 http://dx.doi.org/10.3390/ijms24043496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stella, Giulia M.
Marchiò, Caterina
Bari, Elia
Ferrarotti, Ilaria
Bertuccio, Francesco R.
Di Gennaro, Antonella
Abbott, David Michael
Putignano, Paola
Campo, Ilaria
Torre, Maria Luisa
Corsico, Angelo G.
The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title_full The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title_fullStr The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title_full_unstemmed The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title_short The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
title_sort genes–stemness–secretome interplay in malignant pleural mesothelioma: molecular dynamics and clinical hints
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963101/
https://www.ncbi.nlm.nih.gov/pubmed/36834912
http://dx.doi.org/10.3390/ijms24043496
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