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The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963101/ https://www.ncbi.nlm.nih.gov/pubmed/36834912 http://dx.doi.org/10.3390/ijms24043496 |
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author | Stella, Giulia M. Marchiò, Caterina Bari, Elia Ferrarotti, Ilaria Bertuccio, Francesco R. Di Gennaro, Antonella Abbott, David Michael Putignano, Paola Campo, Ilaria Torre, Maria Luisa Corsico, Angelo G. |
author_facet | Stella, Giulia M. Marchiò, Caterina Bari, Elia Ferrarotti, Ilaria Bertuccio, Francesco R. Di Gennaro, Antonella Abbott, David Michael Putignano, Paola Campo, Ilaria Torre, Maria Luisa Corsico, Angelo G. |
author_sort | Stella, Giulia M. |
collection | PubMed |
description | MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets. |
format | Online Article Text |
id | pubmed-9963101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99631012023-02-26 The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints Stella, Giulia M. Marchiò, Caterina Bari, Elia Ferrarotti, Ilaria Bertuccio, Francesco R. Di Gennaro, Antonella Abbott, David Michael Putignano, Paola Campo, Ilaria Torre, Maria Luisa Corsico, Angelo G. Int J Mol Sci Review MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets. MDPI 2023-02-09 /pmc/articles/PMC9963101/ /pubmed/36834912 http://dx.doi.org/10.3390/ijms24043496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stella, Giulia M. Marchiò, Caterina Bari, Elia Ferrarotti, Ilaria Bertuccio, Francesco R. Di Gennaro, Antonella Abbott, David Michael Putignano, Paola Campo, Ilaria Torre, Maria Luisa Corsico, Angelo G. The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title_full | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title_fullStr | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title_full_unstemmed | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title_short | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
title_sort | genes–stemness–secretome interplay in malignant pleural mesothelioma: molecular dynamics and clinical hints |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963101/ https://www.ncbi.nlm.nih.gov/pubmed/36834912 http://dx.doi.org/10.3390/ijms24043496 |
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