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Placental Mitochondrial Function and Dysfunction in Preeclampsia

The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy...

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Autores principales: Jahan, Fahmida, Vasam, Goutham, Green, Alex E., Bainbridge, Shannon A., Menzies, Keir J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963167/
https://www.ncbi.nlm.nih.gov/pubmed/36835587
http://dx.doi.org/10.3390/ijms24044177
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author Jahan, Fahmida
Vasam, Goutham
Green, Alex E.
Bainbridge, Shannon A.
Menzies, Keir J.
author_facet Jahan, Fahmida
Vasam, Goutham
Green, Alex E.
Bainbridge, Shannon A.
Menzies, Keir J.
author_sort Jahan, Fahmida
collection PubMed
description The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed.
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spelling pubmed-99631672023-02-26 Placental Mitochondrial Function and Dysfunction in Preeclampsia Jahan, Fahmida Vasam, Goutham Green, Alex E. Bainbridge, Shannon A. Menzies, Keir J. Int J Mol Sci Review The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed. MDPI 2023-02-20 /pmc/articles/PMC9963167/ /pubmed/36835587 http://dx.doi.org/10.3390/ijms24044177 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jahan, Fahmida
Vasam, Goutham
Green, Alex E.
Bainbridge, Shannon A.
Menzies, Keir J.
Placental Mitochondrial Function and Dysfunction in Preeclampsia
title Placental Mitochondrial Function and Dysfunction in Preeclampsia
title_full Placental Mitochondrial Function and Dysfunction in Preeclampsia
title_fullStr Placental Mitochondrial Function and Dysfunction in Preeclampsia
title_full_unstemmed Placental Mitochondrial Function and Dysfunction in Preeclampsia
title_short Placental Mitochondrial Function and Dysfunction in Preeclampsia
title_sort placental mitochondrial function and dysfunction in preeclampsia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963167/
https://www.ncbi.nlm.nih.gov/pubmed/36835587
http://dx.doi.org/10.3390/ijms24044177
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