Cargando…
Placental Mitochondrial Function and Dysfunction in Preeclampsia
The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963167/ https://www.ncbi.nlm.nih.gov/pubmed/36835587 http://dx.doi.org/10.3390/ijms24044177 |
_version_ | 1784896185586155520 |
---|---|
author | Jahan, Fahmida Vasam, Goutham Green, Alex E. Bainbridge, Shannon A. Menzies, Keir J. |
author_facet | Jahan, Fahmida Vasam, Goutham Green, Alex E. Bainbridge, Shannon A. Menzies, Keir J. |
author_sort | Jahan, Fahmida |
collection | PubMed |
description | The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed. |
format | Online Article Text |
id | pubmed-9963167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99631672023-02-26 Placental Mitochondrial Function and Dysfunction in Preeclampsia Jahan, Fahmida Vasam, Goutham Green, Alex E. Bainbridge, Shannon A. Menzies, Keir J. Int J Mol Sci Review The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed. MDPI 2023-02-20 /pmc/articles/PMC9963167/ /pubmed/36835587 http://dx.doi.org/10.3390/ijms24044177 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jahan, Fahmida Vasam, Goutham Green, Alex E. Bainbridge, Shannon A. Menzies, Keir J. Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title | Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title_full | Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title_fullStr | Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title_full_unstemmed | Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title_short | Placental Mitochondrial Function and Dysfunction in Preeclampsia |
title_sort | placental mitochondrial function and dysfunction in preeclampsia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963167/ https://www.ncbi.nlm.nih.gov/pubmed/36835587 http://dx.doi.org/10.3390/ijms24044177 |
work_keys_str_mv | AT jahanfahmida placentalmitochondrialfunctionanddysfunctioninpreeclampsia AT vasamgoutham placentalmitochondrialfunctionanddysfunctioninpreeclampsia AT greenalexe placentalmitochondrialfunctionanddysfunctioninpreeclampsia AT bainbridgeshannona placentalmitochondrialfunctionanddysfunctioninpreeclampsia AT menzieskeirj placentalmitochondrialfunctionanddysfunctioninpreeclampsia |