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Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy
During the past decade, researchers have investigated the molecular mechanisms of breast cancer initiation and progression, especially triple-negative breast cancer (TNBC), in order to identify specific biomarkers that could serve as feasible targets for innovative therapeutic strategies development...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963301/ https://www.ncbi.nlm.nih.gov/pubmed/36834660 http://dx.doi.org/10.3390/ijms24043245 |
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author | (Stămat), Liliana-Roxana Balahura Dinescu, Sorina Costache, Marieta |
author_facet | (Stămat), Liliana-Roxana Balahura Dinescu, Sorina Costache, Marieta |
author_sort | (Stămat), Liliana-Roxana Balahura |
collection | PubMed |
description | During the past decade, researchers have investigated the molecular mechanisms of breast cancer initiation and progression, especially triple-negative breast cancer (TNBC), in order to identify specific biomarkers that could serve as feasible targets for innovative therapeutic strategies development. TNBC is characterized by a dynamic and aggressive nature, due to the absence of estrogen, progesterone and human epidermal growth factor 2 receptors. TNBC progression is associated with the dysregulation of nucleotide-binding oligomerization domain-like receptor and pyrin domain-containing protein 3 (NLRP3) inflammasome, followed by the release of pro-inflammatory cytokines and caspase-1 dependent cell death, termed pyroptosis. The heterogeneity of the breast tumor microenvironment triggers the interest of non-coding RNAs’ involvement in NLRP3 inflammasome assembly, TNBC progression and metastasis. Non-coding RNAs are paramount regulators of carcinogenesis and inflammasome pathways, which could help in the development of efficient treatments. This review aims to highlight the contribution of non-coding RNAs that support inflammasome activation and TNBC progression, pointing up their potential for clinical applications as biomarkers for diagnosis and therapy. |
format | Online Article Text |
id | pubmed-9963301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99633012023-02-26 Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy (Stămat), Liliana-Roxana Balahura Dinescu, Sorina Costache, Marieta Int J Mol Sci Review During the past decade, researchers have investigated the molecular mechanisms of breast cancer initiation and progression, especially triple-negative breast cancer (TNBC), in order to identify specific biomarkers that could serve as feasible targets for innovative therapeutic strategies development. TNBC is characterized by a dynamic and aggressive nature, due to the absence of estrogen, progesterone and human epidermal growth factor 2 receptors. TNBC progression is associated with the dysregulation of nucleotide-binding oligomerization domain-like receptor and pyrin domain-containing protein 3 (NLRP3) inflammasome, followed by the release of pro-inflammatory cytokines and caspase-1 dependent cell death, termed pyroptosis. The heterogeneity of the breast tumor microenvironment triggers the interest of non-coding RNAs’ involvement in NLRP3 inflammasome assembly, TNBC progression and metastasis. Non-coding RNAs are paramount regulators of carcinogenesis and inflammasome pathways, which could help in the development of efficient treatments. This review aims to highlight the contribution of non-coding RNAs that support inflammasome activation and TNBC progression, pointing up their potential for clinical applications as biomarkers for diagnosis and therapy. MDPI 2023-02-07 /pmc/articles/PMC9963301/ /pubmed/36834660 http://dx.doi.org/10.3390/ijms24043245 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review (Stămat), Liliana-Roxana Balahura Dinescu, Sorina Costache, Marieta Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title | Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title_full | Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title_fullStr | Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title_full_unstemmed | Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title_short | Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy |
title_sort | regulation of inflammasome by micrornas in triple-negative breast cancer: new opportunities for therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963301/ https://www.ncbi.nlm.nih.gov/pubmed/36834660 http://dx.doi.org/10.3390/ijms24043245 |
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