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Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty

This study aimed to assess clinical application of the Scheimpflug corneal tomography for objective evaluation of corneal optical density in eyes undergoing Descemet’s stripping endothelial keratoplasty (DSEK). In this prospective study, 39 pseudophakic eyes with bullous keratopathy were enrolled. A...

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Autores principales: Piotrowiak-Słupska, Ilona, Kałużny, Bartłomiej J., Malukiewicz, Grażyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963363/
https://www.ncbi.nlm.nih.gov/pubmed/36836087
http://dx.doi.org/10.3390/jcm12041552
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author Piotrowiak-Słupska, Ilona
Kałużny, Bartłomiej J.
Malukiewicz, Grażyna
author_facet Piotrowiak-Słupska, Ilona
Kałużny, Bartłomiej J.
Malukiewicz, Grażyna
author_sort Piotrowiak-Słupska, Ilona
collection PubMed
description This study aimed to assess clinical application of the Scheimpflug corneal tomography for objective evaluation of corneal optical density in eyes undergoing Descemet’s stripping endothelial keratoplasty (DSEK). In this prospective study, 39 pseudophakic eyes with bullous keratopathy were enrolled. All eyes underwent primary DSEK. Ophthalmic examination included best corrected visual acuity (BCVA) measurement, biomicroscopy, Scheimpflug tomography, pachymetry, and endothelial cell count. All measurements were taken preoperatively and within a 2-year follow-up period. Gradual BCVA improvement was observed in all patients. After two years, the mean and median BCVA values were 0.18 logMAR. A decrease in central corneal thickness was noted only during the first 3 months postoperatively and was followed by a gradual increase. Corneal densitometry decreased constantly and most significantly in the first 3 months postoperatively. The consecutive decrease in endothelial cell count of the transplanted cornea was most significant during the first 6 months postoperatively. Six months postoperatively, the strongest correlation (Spearman’s r = −0.41) with BCVA was found for densitometry. This tendency was maintained throughout the entire follow-up period. Corneal densitometry is applicable for objective monitoring of early and late outcomes of endothelial keratoplasty, showing a higher correlation with visual acuity than pachymetry and endothelial cell density.
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spelling pubmed-99633632023-02-26 Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty Piotrowiak-Słupska, Ilona Kałużny, Bartłomiej J. Malukiewicz, Grażyna J Clin Med Article This study aimed to assess clinical application of the Scheimpflug corneal tomography for objective evaluation of corneal optical density in eyes undergoing Descemet’s stripping endothelial keratoplasty (DSEK). In this prospective study, 39 pseudophakic eyes with bullous keratopathy were enrolled. All eyes underwent primary DSEK. Ophthalmic examination included best corrected visual acuity (BCVA) measurement, biomicroscopy, Scheimpflug tomography, pachymetry, and endothelial cell count. All measurements were taken preoperatively and within a 2-year follow-up period. Gradual BCVA improvement was observed in all patients. After two years, the mean and median BCVA values were 0.18 logMAR. A decrease in central corneal thickness was noted only during the first 3 months postoperatively and was followed by a gradual increase. Corneal densitometry decreased constantly and most significantly in the first 3 months postoperatively. The consecutive decrease in endothelial cell count of the transplanted cornea was most significant during the first 6 months postoperatively. Six months postoperatively, the strongest correlation (Spearman’s r = −0.41) with BCVA was found for densitometry. This tendency was maintained throughout the entire follow-up period. Corneal densitometry is applicable for objective monitoring of early and late outcomes of endothelial keratoplasty, showing a higher correlation with visual acuity than pachymetry and endothelial cell density. MDPI 2023-02-16 /pmc/articles/PMC9963363/ /pubmed/36836087 http://dx.doi.org/10.3390/jcm12041552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piotrowiak-Słupska, Ilona
Kałużny, Bartłomiej J.
Malukiewicz, Grażyna
Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title_full Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title_fullStr Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title_full_unstemmed Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title_short Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty
title_sort corneal optical densitometry in the evaluation of 2-year graft function following endothelial keratoplasty
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963363/
https://www.ncbi.nlm.nih.gov/pubmed/36836087
http://dx.doi.org/10.3390/jcm12041552
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