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Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes

Females with type 2 diabetes (T2D) have a 25–50% greater risk of developing cardiovascular disease compared with males. While aerobic exercise training is effective for improving cardiometabolic health outcomes, there is limited sex-segregated evidence on the feasibility of aerobic training in adult...

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Autores principales: O’Gorman, Sian Alice, Miller, Clint Thomas, Rawstorn, Jonathan Charles, Sabag, Angelo, Sultana, Rachelle Noelle, Lanting, Sean Michael, Keating, Shelley Elizabeth, Johnson, Nathan Anthony, Way, Kimberley Larisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963427/
https://www.ncbi.nlm.nih.gov/pubmed/36835790
http://dx.doi.org/10.3390/jcm12041255
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author O’Gorman, Sian Alice
Miller, Clint Thomas
Rawstorn, Jonathan Charles
Sabag, Angelo
Sultana, Rachelle Noelle
Lanting, Sean Michael
Keating, Shelley Elizabeth
Johnson, Nathan Anthony
Way, Kimberley Larisa
author_facet O’Gorman, Sian Alice
Miller, Clint Thomas
Rawstorn, Jonathan Charles
Sabag, Angelo
Sultana, Rachelle Noelle
Lanting, Sean Michael
Keating, Shelley Elizabeth
Johnson, Nathan Anthony
Way, Kimberley Larisa
author_sort O’Gorman, Sian Alice
collection PubMed
description Females with type 2 diabetes (T2D) have a 25–50% greater risk of developing cardiovascular disease compared with males. While aerobic exercise training is effective for improving cardiometabolic health outcomes, there is limited sex-segregated evidence on the feasibility of aerobic training in adults with T2D. A secondary analysis of a 12-week randomized controlled trial examining aerobic training in inactive adults with T2D was conducted. Feasibility outcomes were recruitment, retention, treatment fidelity, and safety. Sex differences and intervention effects were assessed using two-way analyses of variances. Thirty-five participants (14 females) were recruited. The recruitment rate was significantly lower among females (9% versus 18%; p = 0.022). Females in the intervention were less adherent (50% versus 93%; p = 0.016), and experienced minor adverse events more frequently (0.08% versus 0.03%; p = 0.003). Aerobically trained females experienced clinically meaningful reductions in pulse wave velocity (−1.25 m/s, 95%CI [−2.54, 0.04]; p = 0.648), and significantly greater reductions in brachial systolic pressure (−9 mmHg, 95%CI (3, 15); p = 0.011) and waist circumference (−3.8 cm, 95%CI (1.6, 6.1); p < 0.001) than males. To enhance the feasibility of future trials, targeted strategies to improve female recruitment and adherence are needed. Females with T2D may experience greater cardiometabolic health improvements from aerobic training than males.
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spelling pubmed-99634272023-02-26 Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes O’Gorman, Sian Alice Miller, Clint Thomas Rawstorn, Jonathan Charles Sabag, Angelo Sultana, Rachelle Noelle Lanting, Sean Michael Keating, Shelley Elizabeth Johnson, Nathan Anthony Way, Kimberley Larisa J Clin Med Article Females with type 2 diabetes (T2D) have a 25–50% greater risk of developing cardiovascular disease compared with males. While aerobic exercise training is effective for improving cardiometabolic health outcomes, there is limited sex-segregated evidence on the feasibility of aerobic training in adults with T2D. A secondary analysis of a 12-week randomized controlled trial examining aerobic training in inactive adults with T2D was conducted. Feasibility outcomes were recruitment, retention, treatment fidelity, and safety. Sex differences and intervention effects were assessed using two-way analyses of variances. Thirty-five participants (14 females) were recruited. The recruitment rate was significantly lower among females (9% versus 18%; p = 0.022). Females in the intervention were less adherent (50% versus 93%; p = 0.016), and experienced minor adverse events more frequently (0.08% versus 0.03%; p = 0.003). Aerobically trained females experienced clinically meaningful reductions in pulse wave velocity (−1.25 m/s, 95%CI [−2.54, 0.04]; p = 0.648), and significantly greater reductions in brachial systolic pressure (−9 mmHg, 95%CI (3, 15); p = 0.011) and waist circumference (−3.8 cm, 95%CI (1.6, 6.1); p < 0.001) than males. To enhance the feasibility of future trials, targeted strategies to improve female recruitment and adherence are needed. Females with T2D may experience greater cardiometabolic health improvements from aerobic training than males. MDPI 2023-02-04 /pmc/articles/PMC9963427/ /pubmed/36835790 http://dx.doi.org/10.3390/jcm12041255 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
O’Gorman, Sian Alice
Miller, Clint Thomas
Rawstorn, Jonathan Charles
Sabag, Angelo
Sultana, Rachelle Noelle
Lanting, Sean Michael
Keating, Shelley Elizabeth
Johnson, Nathan Anthony
Way, Kimberley Larisa
Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title_full Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title_fullStr Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title_full_unstemmed Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title_short Sex Differences in the Feasibility of Aerobic Exercise Training for Improving Cardiometabolic Health Outcomes in Adults with Type 2 Diabetes
title_sort sex differences in the feasibility of aerobic exercise training for improving cardiometabolic health outcomes in adults with type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963427/
https://www.ncbi.nlm.nih.gov/pubmed/36835790
http://dx.doi.org/10.3390/jcm12041255
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