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Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA

Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis...

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Autores principales: Aedh, Abdullah I., Al-Swedan, Ali Dhafer, Mohammed, Asiri Ahmed, Alwadai, Batool Mubarak, Alyami, Ahlam Yahya, Alsaaed, Esraa Amer, Almurdhimah, Nouf Mubarak, Zaki, Mohamed Soliman, Othman, Alyaa E., Hasan, Abdulkarim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963463/
https://www.ncbi.nlm.nih.gov/pubmed/36828524
http://dx.doi.org/10.3390/tropicalmed8020108
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author Aedh, Abdullah I.
Al-Swedan, Ali Dhafer
Mohammed, Asiri Ahmed
Alwadai, Batool Mubarak
Alyami, Ahlam Yahya
Alsaaed, Esraa Amer
Almurdhimah, Nouf Mubarak
Zaki, Mohamed Soliman
Othman, Alyaa E.
Hasan, Abdulkarim
author_facet Aedh, Abdullah I.
Al-Swedan, Ali Dhafer
Mohammed, Asiri Ahmed
Alwadai, Batool Mubarak
Alyami, Ahlam Yahya
Alsaaed, Esraa Amer
Almurdhimah, Nouf Mubarak
Zaki, Mohamed Soliman
Othman, Alyaa E.
Hasan, Abdulkarim
author_sort Aedh, Abdullah I.
collection PubMed
description Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis factors for acquiring an infection due to A. baumannii compared to that of other nosocomial bacteria. In our study, we employed antibiotics generally prescribed for the initial course of treatment such as colistin, meropenem, amikacin, trimethoprime-sulfamethoxazole, levofloxacin, gentamicin, ciprofloxacin, and piperacillin-tazobactam. We found that the isolated A. baumannii were resistant at a high rate to meropenem, piperacillin–tazobactam, amikacin, levofloxacin, and ciprofloxacin, while they were partially susceptible to trimethoprim-sulfamethoxazole. Our study revealed that A. baumannii was most susceptible to gentamicin and colistin at 85.8% and 92.9%, respectively, whereas the combination of colistin and trimethoprim/sulfamethoxazole was 100% active. The patients were the primary source of infection with A. baumannii, followed by inanimate objects present in the ICU and hospital premises, and then the hospital staff who were taking care of the ICU patients. Gentamicin and colistin were the most sensitive antibiotics; of the 13 tested in total, the rate of drug resistance was above 50%. The very high rate of antibiotic resistance is alarming.
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spelling pubmed-99634632023-02-26 Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA Aedh, Abdullah I. Al-Swedan, Ali Dhafer Mohammed, Asiri Ahmed Alwadai, Batool Mubarak Alyami, Ahlam Yahya Alsaaed, Esraa Amer Almurdhimah, Nouf Mubarak Zaki, Mohamed Soliman Othman, Alyaa E. Hasan, Abdulkarim Trop Med Infect Dis Article Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis factors for acquiring an infection due to A. baumannii compared to that of other nosocomial bacteria. In our study, we employed antibiotics generally prescribed for the initial course of treatment such as colistin, meropenem, amikacin, trimethoprime-sulfamethoxazole, levofloxacin, gentamicin, ciprofloxacin, and piperacillin-tazobactam. We found that the isolated A. baumannii were resistant at a high rate to meropenem, piperacillin–tazobactam, amikacin, levofloxacin, and ciprofloxacin, while they were partially susceptible to trimethoprim-sulfamethoxazole. Our study revealed that A. baumannii was most susceptible to gentamicin and colistin at 85.8% and 92.9%, respectively, whereas the combination of colistin and trimethoprim/sulfamethoxazole was 100% active. The patients were the primary source of infection with A. baumannii, followed by inanimate objects present in the ICU and hospital premises, and then the hospital staff who were taking care of the ICU patients. Gentamicin and colistin were the most sensitive antibiotics; of the 13 tested in total, the rate of drug resistance was above 50%. The very high rate of antibiotic resistance is alarming. MDPI 2023-02-09 /pmc/articles/PMC9963463/ /pubmed/36828524 http://dx.doi.org/10.3390/tropicalmed8020108 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aedh, Abdullah I.
Al-Swedan, Ali Dhafer
Mohammed, Asiri Ahmed
Alwadai, Batool Mubarak
Alyami, Ahlam Yahya
Alsaaed, Esraa Amer
Almurdhimah, Nouf Mubarak
Zaki, Mohamed Soliman
Othman, Alyaa E.
Hasan, Abdulkarim
Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title_full Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title_fullStr Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title_full_unstemmed Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title_short Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
title_sort occurrence of multidrug-resistant strains of acinetobacter spp.: an emerging threat for nosocomial-borne infection in najran region, ksa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963463/
https://www.ncbi.nlm.nih.gov/pubmed/36828524
http://dx.doi.org/10.3390/tropicalmed8020108
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