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Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA
Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963463/ https://www.ncbi.nlm.nih.gov/pubmed/36828524 http://dx.doi.org/10.3390/tropicalmed8020108 |
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author | Aedh, Abdullah I. Al-Swedan, Ali Dhafer Mohammed, Asiri Ahmed Alwadai, Batool Mubarak Alyami, Ahlam Yahya Alsaaed, Esraa Amer Almurdhimah, Nouf Mubarak Zaki, Mohamed Soliman Othman, Alyaa E. Hasan, Abdulkarim |
author_facet | Aedh, Abdullah I. Al-Swedan, Ali Dhafer Mohammed, Asiri Ahmed Alwadai, Batool Mubarak Alyami, Ahlam Yahya Alsaaed, Esraa Amer Almurdhimah, Nouf Mubarak Zaki, Mohamed Soliman Othman, Alyaa E. Hasan, Abdulkarim |
author_sort | Aedh, Abdullah I. |
collection | PubMed |
description | Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis factors for acquiring an infection due to A. baumannii compared to that of other nosocomial bacteria. In our study, we employed antibiotics generally prescribed for the initial course of treatment such as colistin, meropenem, amikacin, trimethoprime-sulfamethoxazole, levofloxacin, gentamicin, ciprofloxacin, and piperacillin-tazobactam. We found that the isolated A. baumannii were resistant at a high rate to meropenem, piperacillin–tazobactam, amikacin, levofloxacin, and ciprofloxacin, while they were partially susceptible to trimethoprim-sulfamethoxazole. Our study revealed that A. baumannii was most susceptible to gentamicin and colistin at 85.8% and 92.9%, respectively, whereas the combination of colistin and trimethoprim/sulfamethoxazole was 100% active. The patients were the primary source of infection with A. baumannii, followed by inanimate objects present in the ICU and hospital premises, and then the hospital staff who were taking care of the ICU patients. Gentamicin and colistin were the most sensitive antibiotics; of the 13 tested in total, the rate of drug resistance was above 50%. The very high rate of antibiotic resistance is alarming. |
format | Online Article Text |
id | pubmed-9963463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99634632023-02-26 Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA Aedh, Abdullah I. Al-Swedan, Ali Dhafer Mohammed, Asiri Ahmed Alwadai, Batool Mubarak Alyami, Ahlam Yahya Alsaaed, Esraa Amer Almurdhimah, Nouf Mubarak Zaki, Mohamed Soliman Othman, Alyaa E. Hasan, Abdulkarim Trop Med Infect Dis Article Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis factors for acquiring an infection due to A. baumannii compared to that of other nosocomial bacteria. In our study, we employed antibiotics generally prescribed for the initial course of treatment such as colistin, meropenem, amikacin, trimethoprime-sulfamethoxazole, levofloxacin, gentamicin, ciprofloxacin, and piperacillin-tazobactam. We found that the isolated A. baumannii were resistant at a high rate to meropenem, piperacillin–tazobactam, amikacin, levofloxacin, and ciprofloxacin, while they were partially susceptible to trimethoprim-sulfamethoxazole. Our study revealed that A. baumannii was most susceptible to gentamicin and colistin at 85.8% and 92.9%, respectively, whereas the combination of colistin and trimethoprim/sulfamethoxazole was 100% active. The patients were the primary source of infection with A. baumannii, followed by inanimate objects present in the ICU and hospital premises, and then the hospital staff who were taking care of the ICU patients. Gentamicin and colistin were the most sensitive antibiotics; of the 13 tested in total, the rate of drug resistance was above 50%. The very high rate of antibiotic resistance is alarming. MDPI 2023-02-09 /pmc/articles/PMC9963463/ /pubmed/36828524 http://dx.doi.org/10.3390/tropicalmed8020108 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aedh, Abdullah I. Al-Swedan, Ali Dhafer Mohammed, Asiri Ahmed Alwadai, Batool Mubarak Alyami, Ahlam Yahya Alsaaed, Esraa Amer Almurdhimah, Nouf Mubarak Zaki, Mohamed Soliman Othman, Alyaa E. Hasan, Abdulkarim Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title | Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title_full | Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title_fullStr | Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title_full_unstemmed | Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title_short | Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA |
title_sort | occurrence of multidrug-resistant strains of acinetobacter spp.: an emerging threat for nosocomial-borne infection in najran region, ksa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963463/ https://www.ncbi.nlm.nih.gov/pubmed/36828524 http://dx.doi.org/10.3390/tropicalmed8020108 |
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