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Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents

Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammator...

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Autores principales: Wang, Aozhe, Zhang, Haifeng, Liu, Jianming, Yan, Zhiyi, Sun, Yaqi, Su, Wantang, Yu, Ji-Guo, Mi, Jing, Zhao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963480/
https://www.ncbi.nlm.nih.gov/pubmed/36834025
http://dx.doi.org/10.3390/ijerph20043329
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author Wang, Aozhe
Zhang, Haifeng
Liu, Jianming
Yan, Zhiyi
Sun, Yaqi
Su, Wantang
Yu, Ji-Guo
Mi, Jing
Zhao, Li
author_facet Wang, Aozhe
Zhang, Haifeng
Liu, Jianming
Yan, Zhiyi
Sun, Yaqi
Su, Wantang
Yu, Ji-Guo
Mi, Jing
Zhao, Li
author_sort Wang, Aozhe
collection PubMed
description Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammatory status modification remains controversial and limited, especially in male adolescents. To answer these questions, twelve untrained male adolescents were recruited and underwent 6 weeks of SIT. The pre- and post-training testing included analyses of peak oxygen consumption (VO(2)peak), biometric data (weight and body composition), serum biochemical parameters (fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, testosterone, and cortisol), inflammatory markers, and targeted lipidomics. After the 6-week SIT, the serum C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β significantly decreased (p < 0.05), whereas IL-6 and IL-10/TNF-α significantly increased (p < 0.05). In addition, the targeted lipidomics revealed changes in 296 lipids, of which 33 changed significantly (p < 0.05, fold change > 1.2 or <1/1.2). The correlation analysis revealed that the changes in the inflammatory markers were closely correlated with the changes in some of the lipids, such as LPC, HexCer, and FFA. In conclusion, the 6-week SIT induced significant changes in the inflammatory markers and circulating lipid composition, offering health benefits to the population.
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spelling pubmed-99634802023-02-26 Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents Wang, Aozhe Zhang, Haifeng Liu, Jianming Yan, Zhiyi Sun, Yaqi Su, Wantang Yu, Ji-Guo Mi, Jing Zhao, Li Int J Environ Res Public Health Article Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammatory status modification remains controversial and limited, especially in male adolescents. To answer these questions, twelve untrained male adolescents were recruited and underwent 6 weeks of SIT. The pre- and post-training testing included analyses of peak oxygen consumption (VO(2)peak), biometric data (weight and body composition), serum biochemical parameters (fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, testosterone, and cortisol), inflammatory markers, and targeted lipidomics. After the 6-week SIT, the serum C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β significantly decreased (p < 0.05), whereas IL-6 and IL-10/TNF-α significantly increased (p < 0.05). In addition, the targeted lipidomics revealed changes in 296 lipids, of which 33 changed significantly (p < 0.05, fold change > 1.2 or <1/1.2). The correlation analysis revealed that the changes in the inflammatory markers were closely correlated with the changes in some of the lipids, such as LPC, HexCer, and FFA. In conclusion, the 6-week SIT induced significant changes in the inflammatory markers and circulating lipid composition, offering health benefits to the population. MDPI 2023-02-14 /pmc/articles/PMC9963480/ /pubmed/36834025 http://dx.doi.org/10.3390/ijerph20043329 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Aozhe
Zhang, Haifeng
Liu, Jianming
Yan, Zhiyi
Sun, Yaqi
Su, Wantang
Yu, Ji-Guo
Mi, Jing
Zhao, Li
Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title_full Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title_fullStr Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title_full_unstemmed Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title_short Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
title_sort targeted lipidomics and inflammation response to six weeks of sprint interval training in male adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963480/
https://www.ncbi.nlm.nih.gov/pubmed/36834025
http://dx.doi.org/10.3390/ijerph20043329
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