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Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes

Mammalian voltage-activated L-type Ca(2+) channels, such as Ca(v)1.2, control transmembrane Ca(2+) fluxes in numerous excitable tissues. Here, we report that the pore-forming α1C subunit of Ca(v)1.2 is reversibly palmitoylated in rat, rabbit, and human ventricular myocytes. We map the palmitoylation...

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Detalles Bibliográficos
Autores principales:	Kuo, Chien-Wen S., Dobi, Sara, Gök, Caglar, Da Silva Costa, Ana, Main, Alice, Robertson-Gray, Olivia, Baptista-Hon, Daniel, Wypijewski, Krzysztof J., Costello, Hannah, Hales, Tim G., MacQuaide, Niall, Smith, Godfrey L., Fuller, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963536/ https://www.ncbi.nlm.nih.gov/pubmed/36745790 http://dx.doi.org/10.1073/pnas.2207887120

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