Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus

Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass sp...

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Detalles Bibliográficos
Autores principales: Dai, Quan, Pang, Li-Ting, Zhang, Fa-Lei, Wang, Gang-Qiang, Li, Xue-Mei, Liu, Ji-Kai, Feng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963684/
https://www.ncbi.nlm.nih.gov/pubmed/36838552
http://dx.doi.org/10.3390/molecules28041564
Descripción
Sumario:Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC(50) values ranging from 5.516 to 19.953 μM.

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