Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus

Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass sp...

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Detalles Bibliográficos
Autores principales: Dai, Quan, Pang, Li-Ting, Zhang, Fa-Lei, Wang, Gang-Qiang, Li, Xue-Mei, Liu, Ji-Kai, Feng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963684/
https://www.ncbi.nlm.nih.gov/pubmed/36838552
http://dx.doi.org/10.3390/molecules28041564
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author Dai, Quan
Pang, Li-Ting
Zhang, Fa-Lei
Wang, Gang-Qiang
Li, Xue-Mei
Liu, Ji-Kai
Feng, Tao
author_facet Dai, Quan
Pang, Li-Ting
Zhang, Fa-Lei
Wang, Gang-Qiang
Li, Xue-Mei
Liu, Ji-Kai
Feng, Tao
author_sort Dai, Quan
collection PubMed
description Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC(50) values ranging from 5.516 to 19.953 μM.
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spelling pubmed-99636842023-02-26 Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus Dai, Quan Pang, Li-Ting Zhang, Fa-Lei Wang, Gang-Qiang Li, Xue-Mei Liu, Ji-Kai Feng, Tao Molecules Article Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC(50) values ranging from 5.516 to 19.953 μM. MDPI 2023-02-06 /pmc/articles/PMC9963684/ /pubmed/36838552 http://dx.doi.org/10.3390/molecules28041564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dai, Quan
Pang, Li-Ting
Zhang, Fa-Lei
Wang, Gang-Qiang
Li, Xue-Mei
Liu, Ji-Kai
Feng, Tao
Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title_full Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title_fullStr Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title_full_unstemmed Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title_short Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
title_sort meroterpenoids with immunosuppressive activity from edible fungus craterellus odoratus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963684/
https://www.ncbi.nlm.nih.gov/pubmed/36838552
http://dx.doi.org/10.3390/molecules28041564
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