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Local and Systemic Effects of Porphyromonas gingivalis Infection
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. ging...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963840/ https://www.ncbi.nlm.nih.gov/pubmed/36838435 http://dx.doi.org/10.3390/microorganisms11020470 |
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author | Chen, William A. Dou, Yuetan Fletcher, Hansel M. Boskovic, Danilo S. |
author_facet | Chen, William A. Dou, Yuetan Fletcher, Hansel M. Boskovic, Danilo S. |
author_sort | Chen, William A. |
collection | PubMed |
description | Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors. |
format | Online Article Text |
id | pubmed-9963840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99638402023-02-26 Local and Systemic Effects of Porphyromonas gingivalis Infection Chen, William A. Dou, Yuetan Fletcher, Hansel M. Boskovic, Danilo S. Microorganisms Review Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors. MDPI 2023-02-13 /pmc/articles/PMC9963840/ /pubmed/36838435 http://dx.doi.org/10.3390/microorganisms11020470 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, William A. Dou, Yuetan Fletcher, Hansel M. Boskovic, Danilo S. Local and Systemic Effects of Porphyromonas gingivalis Infection |
title | Local and Systemic Effects of Porphyromonas gingivalis Infection |
title_full | Local and Systemic Effects of Porphyromonas gingivalis Infection |
title_fullStr | Local and Systemic Effects of Porphyromonas gingivalis Infection |
title_full_unstemmed | Local and Systemic Effects of Porphyromonas gingivalis Infection |
title_short | Local and Systemic Effects of Porphyromonas gingivalis Infection |
title_sort | local and systemic effects of porphyromonas gingivalis infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963840/ https://www.ncbi.nlm.nih.gov/pubmed/36838435 http://dx.doi.org/10.3390/microorganisms11020470 |
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