CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors

Cancer treatments targeting DNA repair deficiencies often encounter drug resistance, possibly due to alternative metabolic pathways that counteract the most damaging effects. To identify such alternative pathways, we screened for metabolic pathways exhibiting synthetic lethality with inhibition of t...

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Detalles Bibliográficos
Autores principales: Li, Haojian, Liu, Yue, Xiao, Yunjie, Wilson, Crystal N., Bai, Hui Jen, Jones, Maxwell D., Wang, Shihchun, DeVore, Jennie E., Maier, Esther Y., Durant, Stephen T., Boufraqech, Myriem, Weyemi, Urbain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963842/
https://www.ncbi.nlm.nih.gov/pubmed/36724254
http://dx.doi.org/10.1073/pnas.2212072120

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