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Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment

Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED w...

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Autores principales: Pérez-Aizpurua, Xabier, Garranzo-Ibarrola, María, Simón-Rodríguez, Carlos, García-Cardoso, Juan Vicente, Chávez-Roa, César, López-Martín, Leticia, Tufet i Jaumot, Jaime Jorge, Alonso-Román, Josué, Maqueda-Arellano, Jesús, Gómez-Jordana, Blanca, Ruiz de Castroviejo-Blanco, Joaquín, Osorio-Ospina, Felipe, González-Enguita, Carmen, García-Arranz, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963846/
https://www.ncbi.nlm.nih.gov/pubmed/36836859
http://dx.doi.org/10.3390/life13020502
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author Pérez-Aizpurua, Xabier
Garranzo-Ibarrola, María
Simón-Rodríguez, Carlos
García-Cardoso, Juan Vicente
Chávez-Roa, César
López-Martín, Leticia
Tufet i Jaumot, Jaime Jorge
Alonso-Román, Josué
Maqueda-Arellano, Jesús
Gómez-Jordana, Blanca
Ruiz de Castroviejo-Blanco, Joaquín
Osorio-Ospina, Felipe
González-Enguita, Carmen
García-Arranz, Mariano
author_facet Pérez-Aizpurua, Xabier
Garranzo-Ibarrola, María
Simón-Rodríguez, Carlos
García-Cardoso, Juan Vicente
Chávez-Roa, César
López-Martín, Leticia
Tufet i Jaumot, Jaime Jorge
Alonso-Román, Josué
Maqueda-Arellano, Jesús
Gómez-Jordana, Blanca
Ruiz de Castroviejo-Blanco, Joaquín
Osorio-Ospina, Felipe
González-Enguita, Carmen
García-Arranz, Mariano
author_sort Pérez-Aizpurua, Xabier
collection PubMed
description Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit.
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spelling pubmed-99638462023-02-26 Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment Pérez-Aizpurua, Xabier Garranzo-Ibarrola, María Simón-Rodríguez, Carlos García-Cardoso, Juan Vicente Chávez-Roa, César López-Martín, Leticia Tufet i Jaumot, Jaime Jorge Alonso-Román, Josué Maqueda-Arellano, Jesús Gómez-Jordana, Blanca Ruiz de Castroviejo-Blanco, Joaquín Osorio-Ospina, Felipe González-Enguita, Carmen García-Arranz, Mariano Life (Basel) Review Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit. MDPI 2023-02-11 /pmc/articles/PMC9963846/ /pubmed/36836859 http://dx.doi.org/10.3390/life13020502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pérez-Aizpurua, Xabier
Garranzo-Ibarrola, María
Simón-Rodríguez, Carlos
García-Cardoso, Juan Vicente
Chávez-Roa, César
López-Martín, Leticia
Tufet i Jaumot, Jaime Jorge
Alonso-Román, Josué
Maqueda-Arellano, Jesús
Gómez-Jordana, Blanca
Ruiz de Castroviejo-Blanco, Joaquín
Osorio-Ospina, Felipe
González-Enguita, Carmen
García-Arranz, Mariano
Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title_full Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title_fullStr Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title_full_unstemmed Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title_short Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
title_sort stem cell therapy for erectile dysfunction: a step towards a future treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963846/
https://www.ncbi.nlm.nih.gov/pubmed/36836859
http://dx.doi.org/10.3390/life13020502
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