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Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy
Background: Corneal edema (CE) affects the outcome of phacoemulsification. Effective ways to predict the CE after phacoemulsification are needed. Methods: On the basis of data from patients conforming to the protocol of the AGSPC trial, 17 variables were selected to predict CE after phacoemulsificat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963919/ https://www.ncbi.nlm.nih.gov/pubmed/36835826 http://dx.doi.org/10.3390/jcm12041290 |
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author | Luo, Yu Xu, Guangcan Li, Hongyu Ma, Tianju Ye, Zi Li, Zhaohui |
author_facet | Luo, Yu Xu, Guangcan Li, Hongyu Ma, Tianju Ye, Zi Li, Zhaohui |
author_sort | Luo, Yu |
collection | PubMed |
description | Background: Corneal edema (CE) affects the outcome of phacoemulsification. Effective ways to predict the CE after phacoemulsification are needed. Methods: On the basis of data from patients conforming to the protocol of the AGSPC trial, 17 variables were selected to predict CE after phacoemulsification by constructing a CE nomogram through multivariate logistic regression, which was improved via variable selection with copula entropy. The prediction models were evaluated using predictive accuracy, the area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA). Results: Data from 178 patients were used to construct prediction models. After copula entropy variable selection, which shifted the variables used for prediction in the CE nomogram from diabetes, best corrected visual acuity (BCVA), lens thickness and cumulative dissipated energy (CDE) to CDE and BCVA in the Copula nomogram, there was no significant change in predictive accuracy (0.9039 vs. 0.9098). There was also no significant difference in AUCs between the CE nomogram and the Copula nomogram (0.9637, 95% CI 0.9329–0.9946 vs. 0.9512, 95% CI 0.9075–0.9949; p = 0.2221). DCA suggested that the Copula nomogram has clinical application. Conclusions: This study obtained a nomogram with good performance to predict CE after phacoemulsification, and showed the improvement of copula entropy for nomogram models. |
format | Online Article Text |
id | pubmed-9963919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99639192023-02-26 Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy Luo, Yu Xu, Guangcan Li, Hongyu Ma, Tianju Ye, Zi Li, Zhaohui J Clin Med Article Background: Corneal edema (CE) affects the outcome of phacoemulsification. Effective ways to predict the CE after phacoemulsification are needed. Methods: On the basis of data from patients conforming to the protocol of the AGSPC trial, 17 variables were selected to predict CE after phacoemulsification by constructing a CE nomogram through multivariate logistic regression, which was improved via variable selection with copula entropy. The prediction models were evaluated using predictive accuracy, the area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA). Results: Data from 178 patients were used to construct prediction models. After copula entropy variable selection, which shifted the variables used for prediction in the CE nomogram from diabetes, best corrected visual acuity (BCVA), lens thickness and cumulative dissipated energy (CDE) to CDE and BCVA in the Copula nomogram, there was no significant change in predictive accuracy (0.9039 vs. 0.9098). There was also no significant difference in AUCs between the CE nomogram and the Copula nomogram (0.9637, 95% CI 0.9329–0.9946 vs. 0.9512, 95% CI 0.9075–0.9949; p = 0.2221). DCA suggested that the Copula nomogram has clinical application. Conclusions: This study obtained a nomogram with good performance to predict CE after phacoemulsification, and showed the improvement of copula entropy for nomogram models. MDPI 2023-02-06 /pmc/articles/PMC9963919/ /pubmed/36835826 http://dx.doi.org/10.3390/jcm12041290 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Luo, Yu Xu, Guangcan Li, Hongyu Ma, Tianju Ye, Zi Li, Zhaohui Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title | Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title_full | Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title_fullStr | Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title_full_unstemmed | Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title_short | Research on Establishing Corneal Edema after Phacoemulsification Prediction Model Based on Variable Selection with Copula Entropy |
title_sort | research on establishing corneal edema after phacoemulsification prediction model based on variable selection with copula entropy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963919/ https://www.ncbi.nlm.nih.gov/pubmed/36835826 http://dx.doi.org/10.3390/jcm12041290 |
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