Cargando…

Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer

In recent years, combining different types of therapy has emerged as an advanced strategy for cancer treatment. In these combination therapies, oral delivery of anticancer drugs is more convenient and compliant. This study developed an irinotecan/rapamycin-loaded oral lecithin-based self-nanoemulsif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yu-Hsuan, Chen, Ling-Chun, Cheng, Wen-Ting, Wei, Pu-Sheng, Hsieh, Chien-Ming, Sheu, Ming-Thau, Lin, Shyr-Yi, Ho, Hsiu-O, Lin, Hong-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963937/ https://www.ncbi.nlm.nih.gov/pubmed/36839795 http://dx.doi.org/10.3390/pharmaceutics15020473

Ejemplares similares

CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas
por: Chen, Ling-Chun, et al.
Publicado: (2021)

A Novel Composite Hydrogel Composed of Formic Acid-Decellularized Pepsin-Soluble Extracellular Matrix Hydrogel and Sacchachitin Hydrogel as Wound Dressing to Synergistically Accelerate Diabetic Wound Healing
por: Hsieh, Chien-Ming, et al.
Publicado: (2020)

Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer
por: Cheng, Wei-Jie, et al.
Publicado: (2022)

Lecithin-Stabilized Polymeric Micelles (L(sb)PMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination with Doxorubicin
por: Chang, Chia-En, et al.
Publicado: (2018)

Carfilzomib and Paclitaxel Co-Loaded Protein Nanoparticles an Effective Therapy Against Pancreatic Adenocarcinomas
por: Cheng, Wen-Ting, et al.
Publicado: (2021)

Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer
por: Chang, Chia-En, et al.
Publicado: (2018)

Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics
por: Hung, Sheng-Feng, et al.
Publicado: (2014)

Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity
por: Cheng, Wei-Jie, et al.
Publicado: (2021)

Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery
por: Chen, Ling-Chun, et al.
Publicado: (2023)

Preclinical Synergistic Combination Therapy of Lurbinectedin with Irinotecan and 5-Fluorouracil in Pancreatic Cancer
por: Tummala, Tej, et al.
Publicado: (2023)

Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib
por: Lin, Hong-Liang, et al.
Publicado: (2020)

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
por: Lin, Hong-Liang, et al.
Publicado: (2021)

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors
por: Su, Chia-Yu, et al.
Publicado: (2018)

Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance
por: Jang, Hyun Joo, et al.
Publicado: (2016)

Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo
por: Chen, Ya-Hui, et al.
Publicado: (2020)

In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate
por: Lin, You-Meei, et al.
Publicado: (2011)

TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
por: Tsai, Shin-Han, et al.
Publicado: (2009)

Formulation Development and Toxicity Assessment of Triacetin Mediated Nanoemulsions as Novel Delivery Systems for Rapamycin
por: Sobhani, Hamideh, et al.
Publicado: (2015)

Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment
por: Lin, Chien-Ju, et al.
Publicado: (2023)

Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy
por: Cheng, Wei-Jie, et al.
Publicado: (2018)

Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy
por: Chen, Ting-Yu, et al.
Publicado: (2020)

The Effect of Nanoemulsion as a Carrier of Hydrophilic Compound for Transdermal Delivery
por: Tsai, Ming-Jun, et al.
Publicado: (2014)

Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
por: Chen, Ying-Chen, et al.
Publicado: (2013)

Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies
por: Sheu, Ming-Thau, et al.
Publicado: (2017)

Publisher Correction: Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies
por: Sheu, Ming-Thau, et al.
Publicado: (2018)

The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion
por: Liang, Yu-Chih, et al.
Publicado: (2020)

A novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver
por: Melancon, Marites P., et al.
Publicado: (2021)

Development of Irinotecan Liposome Armed with Dual-Target Anti-Epidermal Growth Factor Receptor and Anti-Fibroblast Activation Protein-Specific Antibody for Pancreatic Cancer Treatment
por: Lin, Hung-Jun, et al.
Publicado: (2022)

Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
por: Lu, Hsien-Tsung, et al.
Publicado: (2013)

Development and characterization of dilutable self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparation of nanosized particulates
por: Lin, Shen-Fu, et al.
Publicado: (2013)

Combining the mammalian target of rapamycin inhibitor, rapamycin, with resveratrol has a synergistic effect in multiple myeloma
por: Jin, Hong-Guang, et al.
Publicado: (2018)

Prior irinotecan exposure does not preclude benefit to liposomal irinotecan in patients with metastatic pancreatic ductal adenocarcinoma
por: Yu, Kenneth H., et al.
Publicado: (2023)

Rapamycin-Loaded, Capryol(TM) 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, Characterization and Toxicity Assessment
por: Sobhani, Hamideh, et al.
Publicado: (2018)

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles
por: Chen, Ying-Chen, et al.
Publicado: (2015)

Swelling/Floating Capability and Drug Release Characterizations of Gastroretentive Drug Delivery System Based on a Combination of Hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose
por: Chen, Ying-Chen, et al.
Publicado: (2015)

Liposomal Irinotecan: A Review in Metastatic Pancreatic Adenocarcinoma
por: Frampton, James E.
Publicado: (2020)

Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
por: Chen, Yi-Qing, et al.
Publicado: (2021)

Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice
por: de Sá Coutinho, Diego, et al.
Publicado: (2020)

Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives
por: Salvia-Trujillo, Laura, et al.
Publicado: (2016)

Emerging role of nanoemulsions in oral health management
por: Narang, Jasjeet Kaur, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r8hs91kp2o9fopfvom3m5kglme