Facile Synthesis of Hollow Fe(3)O(4)-rGO Nanocomposites for the Electrochemical Detection of Acetaminophen

Acetaminophen (AC) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic drug. Herein, a new type of hollow Fe(3)O(4)-rGO/GCE electrode was prepared for electrochemical detection of AC through a three-step approach involving a solvothermal method for the synthesis of hollow Fe(3)O(4) and the chemical reduction of graphene oxide (GO) for reduced graphene oxide (rGO) and Fe(3)O(4)-rGO nanocomposites modified on the glassy carbon electrode (GCE) surface. The as-prepared Fe(3)O(4)-rGO nanocomposites were characterized using a transmission electron microscope (TEM), X-ray diffraction (XRD), and a magnetic measurement system (SQUID-VSM). The magnetic Fe(3)O(4)-rGO/GCE electrodes were employed for the electrochemical detection of AC using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) and exhibited an ultra-high selectivity and accuracy, a low detection limit of 0.11 µmol/L with a wider linear range from 5 × 10(−7) to 10(−4) mol/L, and high recovery between 100.52% and 101.43%. The obtained Fe(3)O(4)-rGO-modified GCE displays great practical significance for the detection of AC in drug analysis.