Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy

Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he d...

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Autores principales: Bierbaum, Sibylle, Fischer, Veronika, Briedigkeit, Lutz, Werner, Claudius, Hengel, Hartmut, Huzly, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964174/
https://www.ncbi.nlm.nih.gov/pubmed/36851187
http://dx.doi.org/10.3390/vaccines11020309
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author Bierbaum, Sibylle
Fischer, Veronika
Briedigkeit, Lutz
Werner, Claudius
Hengel, Hartmut
Huzly, Daniela
author_facet Bierbaum, Sibylle
Fischer, Veronika
Briedigkeit, Lutz
Werner, Claudius
Hengel, Hartmut
Huzly, Daniela
author_sort Bierbaum, Sibylle
collection PubMed
description Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as “zoster sine herpete”.
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spelling pubmed-99641742023-02-26 Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy Bierbaum, Sibylle Fischer, Veronika Briedigkeit, Lutz Werner, Claudius Hengel, Hartmut Huzly, Daniela Vaccines (Basel) Communication Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as “zoster sine herpete”. MDPI 2023-01-30 /pmc/articles/PMC9964174/ /pubmed/36851187 http://dx.doi.org/10.3390/vaccines11020309 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bierbaum, Sibylle
Fischer, Veronika
Briedigkeit, Lutz
Werner, Claudius
Hengel, Hartmut
Huzly, Daniela
Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title_full Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title_fullStr Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title_full_unstemmed Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title_short Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
title_sort meningitis without rash after reactivation of varicella vaccine strain in a 12-year-old immunocompetent boy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964174/
https://www.ncbi.nlm.nih.gov/pubmed/36851187
http://dx.doi.org/10.3390/vaccines11020309
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